Covalent binding of human two-domain CD4 to an HIV-1 subtype C SOSIP.664 trimer modulates its structural dynamics

Autor:	Nancy L. Tumba, Previn Naicker, Stoyan Stoychev, Mark A. Killick, Gavin R. Owen, Maria A. Papathanasopoulos
Rok vydání:	2022
Předmět:	CD4 Antigens HIV-1 env Gene Products Human Immunodeficiency Virus Biophysics Humans Cell Biology HIV Envelope Protein gp120 Protein Multimerization Antibodies Neutralizing Molecular Biology Biochemistry
Zdroj:	Biochemical and Biophysical Research Communications. 612:181-187
ISSN:	0006-291X
Popis:	The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) mediates host cell infection by binding to the cellular receptor CD4. Recombinant Env bound to CD4 has been explored for its potential as an HIV vaccine immunogen as receptor binding exposes otherwise shielded, conserved functional sites. Previous preclinical studies showed an interchain disulphide linkage facilitated between Env and 2dCD4
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e81e976171f066ef1a3e799cb1bd2ab5 https://doi.org/10.1016/j.bbrc.2022.04.101 Zobrazit plný text záznamu Full Text from ScienceDirect