Dantrolene sodium reverses the increase in cAMP response element and TPA responsive element DNA-binding activity in the rabbit brain following haloperidol administration and heat stress
| Autor: | Norio Taniguchi, Masatoshi Takeda, Ichiro Tsujio, Norio Ogawa, Hisashi Tanii, Emi Iwata, Takashi Kudo, Masato Asanuma |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Central nervous system Response element Hypothalamus Striatum Heat Stress Disorders Dantrolene Dantrolene Sodium Internal medicine medicine Haloperidol Animals Cyclic AMP Response Element-Binding Protein Brain Chemistry Muscle Relaxants Central Chemistry General Neuroscience DNA General Medicine Neostriatum Psychiatry and Mental health medicine.anatomical_structure Endocrinology Neurology Mechanism of action Rabbits Neurology (clinical) medicine.symptom hormones hormone substitutes and hormone antagonists Antipsychotic Agents medicine.drug |
| Zdroj: | Psychiatry and Clinical Neurosciences. 51:415-420 |
| ISSN: | 1440-1819 1323-1316 |
| DOI: | 10.1111/j.1440-1819.1997.tb02610.x |
| Popis: | Using electrophoretic mobility-shift assay (EMSA), we examined DNA-binding activity of cAMP response element (CRE), onto its responsive element CRE, as well as TPA responsive element (TRE) in the medial hypothalamus and striatum of the experimental rabbits administered with haloperidol under heat stress exposure and studied the effects of dantrolene sodium to the transcriptional factor. In EMSA with nuclear extracts from the rabbit brain, the DNA-binding activities of CRE and TRE in medial hypothalamus and striatum increased following haloperidol and heat stress. These increases were maintained by coadministration with atropine. The treatment with dantrolene sodium markedly reversed such increases. The alterations of activities of these transcriptional factors may reflect the therapeutic effect of dantrolene sodium. |
| Databáze: | OpenAIRE |
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