Antinociceptive, Anti-inflammatory Effects and Safety of Ziziphus mistol Fruits
| Autor: | Nancy Vera, Marcos Adrian Reynoso, A. Daud, María Belizán, Alvaro Sánchez Riera |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.drug_class Otras Ciencias Biológicas Analgesic Pharmacology Anti-inflammatory purl.org/becyt/ford/1 [https] Ciencias Biológicas 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine purl.org/becyt/ford/1.6 [https] ZIZIPHUS MISTOL biology business.industry Ziziphus mistol ANTINOCICEPTIVE biology.organism_classification Acute toxicity Carrageenan 030104 developmental biology Opioid chemistry SAFETY 030220 oncology & carcinogenesis Toxicity Rhamnaceae business ANTIINFLAMMATORY CIENCIAS NATURALES Y EXACTAS medicine.drug |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 0975-248X |
| DOI: | 10.25004/ijpsdr.2016.080207 |
| Popis: | Ziziphus mistol Griseb. (Rhamnaceae), popularly known as ?mistol,? is widely distributed throughout Perú, Bolivia, Paraguay and Argentina. Its fruit is consumed in different forms in several argentinean communities. The present study was carried out to investigate the medicinal properties and safety of Ziziphus mistol (mistol) fruits ethanol and aqueous extracts and arrope. Antinociceptive activity was assessed using the formalin, acetic acid-induced writhing and tail-flick tests in rats. Anti-inflammatory effects were determinated through carrageenan induced edema test and cotton pellet-induced granuloma formation, in rats. The safety was evaluated with test of acute toxicity (48 hs) and sub-chronic toxicity (91 days).All extracts (1,000 mg / kg body weight) showed significant inhibition (P |
| Databáze: | OpenAIRE |
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