A comparison of fixed regimens for obtaining human cleaving oocytes for research purposes
| Autor: | Allan Templeton, R.R. Angell, Ioannis E. Messinis, John Aitken |
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| Rok vydání: | 1986 |
| Předmět: |
Adult
Ovulation medicine.medical_specialty Cleavage Stage Ovum media_common.quotation_subject medicine.medical_treatment Fertilization in Vitro Chorionic Gonadotropin Clomiphene Andrology Human fertilization Ovarian Follicle Ovulation Induction Follicular phase Humans Medicine Ovarian follicle Volunteer media_common Gynecology business.industry Research Obstetrics and Gynecology Embryo Transfer Embryo transfer Regimen medicine.anatomical_structure Oocytes Female Ovulation induction business |
| Zdroj: | BJOG: An International Journal of Obstetrics and Gynaecology. 93:39-42 |
| ISSN: | 1471-0528 1470-0328 |
| Popis: | A fixed schedule for ovarian stimulation and follicular aspiration, previously used in our department for research purposes, was modified in an attempt to increase the recovery and cleavage rates of the oocytes. Three different clomiphene regimens were used to stimulate the ovaries of normal volunteer women requesting laparoscopic sterilization (50 mg and 150 mg daily for 5 days, and 50 mg daily for 10 days). Oocytes were recovered from 83% of the aspirated follicles, i.e. 1.6 oocytes/patient: 65% of the oocytes cleaved after in-vitro fertilization and, on average, 1.0 cleaving egg was obtained per patient. There were no differences in the recovery and cleavage rates between the three clomiphene regimens. It is concluded that a sufficient number of cleaving embryos for research purposes can be generated with the present fixed regimen, which offers little inconvenience to the volunteers as the day of egg recovery can be predicted some time in advance. |
| Databáze: | OpenAIRE |
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