Genetic structures of invasive Streptococcus pneumoniae isolates from Korean children obtained between 1995 and 2013
| Autor: | Yun Kyung Kim, Kyung Hyo Kim, Ki Wook Yun, Hye Kyung Cho, Eun Young Cho, Chun Soo Kim, Taekjin Lee, Hwang Min Kim, Chi Eun Oh, Su Eun Park, Yae Jean Kim, Eun Hwa Choi, Jina Lee, Young Jin Hong, Sung Hee Oh, Jin Han Kang, Hyunju Lee, Dong Soo Kim, Young Youn Choi, Byung Wook Eun, Dae Sun Jo, Nam Hee Kim, Hoan Jong Lee, Kwang Nam Kim |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
DNA
Bacterial Male 0301 basic medicine Serotype medicine.medical_specialty Adolescent Genotype 030106 microbiology Multilocus sequence typing Microbial Sensitivity Tests Biology Serogroup medicine.disease_cause Pneumococcal Infections Pneumococcal conjugate vaccine Microbiology lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Medical microbiology Drug Resistance Bacterial Republic of Korea Streptococcus pneumoniae Prevalence medicine Humans lcsh:RC109-216 030212 general & internal medicine Invasive pneumococcal diseases Child Children Genetic Variation Infant Anti-Bacterial Agents Penicillin Infectious Diseases Parasitology Child Preschool Female medicine.drug |
| Zdroj: | BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-11 (2018) |
| ISSN: | 1471-2334 |
| DOI: | 10.1186/s12879-018-3177-7 |
| Popis: | Background Understanding the population genetics of pneumococci will allow detection of changes in the prevalence of circulating genotypes and evidence for capsular switching. We aimed to analyze the genetic structure of invasive pneumococcal isolates obtained from children before and after the use of pneumococcal conjugate vaccines (PCVs) in Korea. Methods A total of 285 invasive pneumococcal isolates were analyzed using serotyping, multilocus sequence typing, and antimicrobial susceptibility testing. We classified the isolation year to pre-PCV7 (1995–2003; n = 70), post-PCV7 (2004–2010; n = 142), and post-PCV13 (2011–2013; n = 73) periods. Results Of the 10 clonal complexes (CCs), antibiotic-resistant international clones, CC320 (31.6%), CC81 (14.7%), and CC166 (6.7%) were the main complexes. Serotype 19A was the main serotype of CC320 throughout the periods. Serotypes of CC81 mainly comprised of 23F (53.3%) in pre-PCV7 period and replaced by non-vaccine types (NVTs; 6C [10%], 13 [30%], 15A [40%], and 15B/C [20%]) in post-PCV13 period. The main serotype responsible for CC166 also changed from 9 V (80%) in pre-PCV7 to NVT 11A (50%) in post-PCV13 periods. Non-susceptibility to penicillin (42.3%) was the highest in CC320, increasing from 0 to 76%. Conclusion The genetic structures of invasive pneumococcal isolates in Korean children have changed concomitantly with serotype after the implementation of PCVs. |
| Databáze: | OpenAIRE |
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