Pulmonary endothelinergic system in experimental congestive heart failure
| Autor: | Paul Mulder, Monique Philippe, Delphine Lepailleur-Enouf, Jean-Paul Henry, Liliane Louedec, Giorgia Egidy, Jean-Baptiste Michel |
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| Přispěvatelé: | U 460, Institut National de la Santé et de la Recherche Médicale (INSERM), Pathologie vasculaire et endocrinologie rénale - Chaire de médecine expérimentale (INSERM U36), Collège de France (CdF (institution))-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2001 |
| Předmět: |
Male
Physiology [SDV]Life Sciences [q-bio] heart failure receptors Endothelin-Converting Enzymes 030204 cardiovascular system & hematology Endothelins 0302 clinical medicine Aspartic Acid Endopeptidases Endothelial dysfunction Lung Aorta 0303 health sciences Endothelin-1 Receptors Endothelin Metalloendopeptidases Peptide secretion Receptor Endothelin A Receptor Endothelin B 3. Good health medicine.anatomical_structure cardiovascular system Cardiology Cardiology and Cardiovascular Medicine Endothelin receptor medicine.hormone medicine.medical_specialty Heart Ventricles Diastole 03 medical and health sciences Organ Culture Techniques Physiology (medical) Internal medicine medicine Animals RNA Messenger Protein Precursors Rats Wistar Muscle Skeletal 030304 developmental biology Analysis of Variance business.industry medicine.disease Endothelin 1 Rats Pleural Effusion Endocrinology Heart failure gene expression endothelins business |
| Zdroj: | Cardiovascular Research Cardiovascular Research, Oxford University Press (OUP), 2001, 49 (2), pp.330-9. ⟨10.1016/s0008-6363(00)00264-9⟩ |
| ISSN: | 0008-6363 |
| DOI: | 10.1016/s0008-6363(00)00264-9 |
| Popis: | International audience; Objectives: Endothelin-1 (ET-1), plays an important role in the pathophysiology of CHF and the pulmonary endothelium is an early hemodynamic target in diastolic left ventricular dysfunction. Therefore we hypothesized that the lung is a main source of humoral endothelin in CHF and that its secretion is proportional to the degree of heart failure. Methods and results: We used rats with coronary artery ligation as an experimental model of either compensated or decompensated heart failure, depending on infarct size. Reverse transcriptase polymerase chain reaction (RT-PCR) revealed that in the lung, the expression of preproET-1 mRNA was higher in decompensated HF than in control and compensated HF rats (P |
| Databáze: | OpenAIRE |
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