Atlas ofSchistosoma mansonilong non-coding RNAs and their expression correlation to protein-coding genes
| Autor: | Adriana S. A. Pereira, Elton J R Vasconcelos, Murilo S. Amaral, Vinicius Mesel, Sergio Verjovski-Almeida, Lucas Ferreira daSilva, Guilherme M. Lavezzo, David S. Pires |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
030231 tropical medicine ved/biology.organism_classification_rank.species Computational biology Biology General Biochemistry Genetics and Molecular Biology Transcriptome Open Reading Frames 03 medical and health sciences 0302 clinical medicine Databases Genetic Gene expression Animals Parasites Model organism Gene Regulation of gene expression ved/biology EXPRESSÃO GÊNICA RNA Schistosoma mansoni biology.organism_classification Open reading frame 030104 developmental biology Gene Expression Regulation RNA Long Noncoding Original Article General Agricultural and Biological Sciences Information Systems |
| Zdroj: | Database: The Journal of Biological Databases and Curation Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1758-0463 |
| Popis: | Long non-coding RNAs (lncRNAs) have been widely discovered in several organisms with the help of high-throughput RNA sequencing. LncRNAs are over 200 nt-long transcripts that do not have protein-coding (PC) potential, having been reported in model organisms to act mainly on the overall control of PC gene expression. Little is known about the functionality of lncRNAs in evolutionarily ancient non-model metazoan organisms, like Schistosoma mansoni, the parasite that causes schistosomiasis, one of the most prevalent infectious-parasitic diseases worldwide. In a recent transcriptomics effort, we identified thousands of S. mansoni lncRNAs predicted to be functional along the course of parasite development. Here, we present an online catalog of each of the S. mansoni lncRNAs whose expression is correlated to PC genes along the parasite life-cycle, which can be conveniently browsed and downloaded through a new web resource http://verjolab.usp.br. We also provide access now to navigation on the co-expression networks disclosed in our previous publication, where we correlated mRNAs and lncRNAs transcriptional patterns across five life-cycle stages/forms, pinpointing biological processes where lncRNAs might act upon. Database URL: http://verjolab.usp.br |
| Databáze: | OpenAIRE |
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