CA 15-3 and bone scintigraphy in the follow-up of breast cancer
| Autor: | M. Seddiki, F. Montravers, V. Izrael, C. Philippe, J. N. Talbot, S. Uzan, N. Younsi |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
0301 basic medicine
Adult Cancer Research medicine.medical_specialty Clinical Biochemistry CA 15-3 Pain Bone Neoplasms Breast Neoplasms Scintigraphy Sensitivity and Specificity Bone and Bones Pathology and Forensic Medicine Metastasis 03 medical and health sciences 0302 clinical medicine Breast cancer Predictive Value of Tests medicine Biomarkers Tumor Humans Radionuclide Imaging Tumor marker Aged Neoplasm Staging Retrospective Studies Aged 80 and over medicine.diagnostic_test business.industry Carcinoma Mucin-1 Bone metastasis Retrospective cohort study Middle Aged medicine.disease Surgery Carcinoembryonic Antigen Neoplasm Proteins 030104 developmental biology Oncology Bone scintigraphy Evaluation Studies as Topic 030220 oncology & carcinogenesis Female Radiology business Follow-Up Studies |
| Zdroj: | The International journal of biological markers. 12(4) |
| ISSN: | 0393-6155 |
| Popis: | By means of the retrospective study of the clinical records of 158 women followed for breast cancer, we aimed to evaluate the consequences of a non-systematic indication for bone scan (BS) based either on CA 15-3 levels alone or a combination of tumor marker levels and clinical criteria. With the first option, the negative predictive value was 95% and 82% of the BS would have been avoided. With the second option, the negative predictive value was 97% and 59% of the BS would have been avoided. Furthermore, the preliminary results of a longitudinal study showed that those patients with normal CA 15-3 levels and positive bone scans showed a subsequent rise in CA 15-3 levels which frequently became elevated with an average delay of 15 months. Omission of systematic bone scans in the follow-up of breast cancer patients is likely to lead to a delay in the diagnosis of bone metastasis in 3% to 5%, the consequences of which have to be examined carefully. |
| Databáze: | OpenAIRE |
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