Sleep duration and insomnia in the elderly: associations with blood pressure variability and carotid artery remodeling
| Autor: | Kazuomi Kario, Satoshi Hoshide, Mami Nishikawa, Kazuyuki Shimada, Michiaki Nagai |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Coefficient of variation Carotid arteries Blood Pressure Hyperlipidemias Carotid Intima-Media Thickness Sex Factors Vascular Stiffness Risk Factors Internal medicine Sleep Initiation and Maintenance Disorders mental disorders Internal Medicine medicine Insomnia Diabetes Mellitus Humans Aged Aged 80 and over business.industry Smoking medicine.disease Sleep in non-human animals Blood pressure Carotid Arteries Cardiovascular Diseases Anesthesia Long sleep Hypertension Arterial stiffness Cardiology Female medicine.symptom business Sleep Sleep duration |
| Zdroj: | American journal of hypertension. 26(8) |
| ISSN: | 1941-7225 |
| Popis: | BACKGROUND Recent studies have shown that short and long sleep durations and insomnia are associated with increased home-measured blood pressure (BP) variability, which in turn has a relationship with arterial stiffness. However, the determinants for visit-to-visit systolic blood pressure (SBP) variability have rarely been investigated in relation to sleep duration, insomnia, and carotid arterial stiffness. METHOD The subjects were 201 elderly individuals (79.9±6.4 years old) with one or more cardiovascular risks. Based on 12 visits, visit-to-visit BP variability (expressed as a coefficient of variation [CV]) and δ (maximum - minimum) BP were measured. Self-reported sleep duration and insomnia questionnaires were used to classify the patients according to sleep duration period and insomnia status. RESULTS After multivariable adjustment, long sleep duration (≥ 9 hours per night) had significant positive associations with SBP δ (P < 0.05), while persistent insomnia had significant positive associations with SBP CV (P < 0.05) and δ (P < 0.01). Additionally, significant interactions were found in terms of long sleep duration by carotid artery stiffness parameter β (P < 0.05), persistent insomnia by intima-media thickness (P < 0.01), and persistent insomnia by stiffness parameter β (P < 0.05) for SBP δ. CONCLUSION In elderly patients at high risk for cardiovascular disease, long sleep duration as well as persistent insomnia were significantly associated with higher visit-to-visit BP variability. Long sleep duration and persistent insomnia each had synergetic interactions with carotid artery stiffness and with visit-to-visit BP variability. |
| Databáze: | OpenAIRE |
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