Increased microparticle levels in middle-aged and elderly patients with insomnia may be involved in the pathogenesis of arteriosclerosis
| Autor: | Bin Xu, Wei Guo, Yue Jiang, Li Ma, Ning Zhang, Li-Ming Luo, Li-Ge Liu, Chen Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Blood Platelets
Male CD31 congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Endothelium CD11a 030204 cardiovascular system & hematology 030230 surgery Gastroenterology Monocytes Pathogenesis 03 medical and health sciences 0302 clinical medicine Antigens CD Cell-Derived Microparticles Risk Factors Sleep Initiation and Maintenance Disorders Internal medicine mental disorders medicine Humans Platelet skin and connective tissue diseases Sleep disorder business.industry Case-control study nutritional and metabolic diseases Arteriosclerosis Middle Aged Atherosclerosis Flow Cytometry medicine.disease medicine.anatomical_structure Case-Control Studies Disease Progression Female Endothelium Vascular Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | International Angiology. 39 |
| ISSN: | 1827-1839 0392-9590 |
| DOI: | 10.23736/s0392-9590.19.04261-5 |
| Popis: | BACKGROUND Insomnia may affect vascular factors and promote arteriosclerosis. Microparticles (MPs) are a heterogeneous group of bioactive small vesicles that can be found in blood and body fluids following activation, necrosis or apoptosis of virtually any eukaryotic cells. MPs are believed to participate in the pathogenesis of atherosclerosis. Few studies have been concerned with the microparticle level in patients with sleep disorder. The purpose of the present study is to measure the levels of endothelial microparticles (EMPs), platelet microparticles (PMPs) and leukocyte-derived microparticles (LMPs) in middle-aged and elderly patients with or without insomnia. METHODS Patients with insomnia (N.=30) and without insomnia (N.=18) were enrolled. The insomnia group covered patients with chronic insomnia (N.=16) and acute insomnia (N.=14). Levels of EMPs (CD31 +, CD62E +) and PMPs (CD41a +, CD42a +) and granulocyte-derived (CD11a +) MPs were measured. Flow cytometry was performed on the Beckman Coulter analyzer. Reference gate was defined for the level of MPs using 0.22-0.45-0.88μm microspheres, and the size gate for MPs was 0.5-1.0μm. RESULTS Of all types of MPs detected, the levels of CD31 +MPs, CD62E +MPs and CD11a +MPs were significantly higher in the insomnia group than in the non-insomnia group (P |
| Databáze: | OpenAIRE |
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