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The effects of diets on urinary and fecal excretion of cadmium (Cd), copper (Cu), and zinc (Zn) were examined after loading Cd to a maximum concentration in the livers of rats. The amount of diet and volume of water taken upad libitum by the rats were also traced throughout. The amount of Cd excreted into urine was dramatically increased immediately after changing to a low protein diet, while that excreted into the feces was slightly decreased (not significant). Zn and Cu excreted into the urine were highly and significantly increased in amount by Cd loading but less affected by diets (not significant). However, Zn and Cu excreted into the feces were lowered by the low protein diet due to the low content of the two metals in this diet. Thus, Cd, selectively released from the liver after changing to a low protein diet, was excreted primarily in the urine. |
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