Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release
| Autor: | Mariska Bos, Chris Oerlemans, Wouter Bult, Wim E. Hennink, J. Frank W. Nijsen, Gert Storm |
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| Rok vydání: | 2010 |
| Předmět: |
theranostics
Biodistribution Polymers micelles CELL LUNG-CANCER THERMALLY SENSITIVE MICELLES Pharmaceutical Science Antineoplastic Agents Pharmacology triggered release Micelle Drug Delivery Systems In vivo Neoplasms BLOCK-COPOLYMER MICELLES Humans Pharmacology (medical) Chelation Clinical Trials as Topic IN-VIVO EVALUATION DRUG-DELIVERY SYSTEMS Chemistry Organic Chemistry imaging nanomedicine CYCLIC ORTHOESTER GROUPS Drug delivery Biophysics PLURONIC P105 MICELLES Molecular Medicine Liberation Nanomedicine CONTRAST AGENTS Expert Review Magic bullet F-19 MAGNETIC-RESONANCE PHASE-II TRIAL Biotechnology |
| Zdroj: | Pharmaceutical Research |
| ISSN: | 1573-904X 0724-8741 |
| DOI: | 10.1007/s11095-010-0233-4 |
| Popis: | Micelles are colloidal particles with a size around 5–100 nm which are currently under investigation as carriers for hydrophobic drugs in anticancer therapy. Currently, five micellar formulations for anticancer therapy are under clinical evaluation, of which Genexol-PM has been FDA approved for use in patients with breast cancer. Micelle-based drug delivery, however, can be improved in different ways. Targeting ligands can be attached to the micelles which specifically recognize and bind to receptors overexpressed in tumor cells, and chelation or incorporation of imaging moieties enables tracking micelles in vivo for biodistribution studies. Moreover, pH-, thermo-, ultrasound-, or light-sensitive block copolymers allow for controlled micelle dissociation and triggered drug release. The combination of these approaches will further improve specificity and efficacy of micelle-based drug delivery and brings the development of a ‘magic bullet’ a major step forward. |
| Databáze: | OpenAIRE |
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