Mycobacterium tuberculosis var. tuberculosis infection in two captive black capuchins (Sapajus nigritus) in Southern Brazil
Autor: | Paulo Guilherme Carniel Wagner, Bruna Correa Lopes, Luciana Sonne, Fabiana Quoos Mayer, Franciele Maboni Siqueira, Fernando Froner Argenta, Saulo Petinatti Pavarini, David Driemeier, Paula Augusto Taunde, Luiza Presser Ehlers, Matheus Viezzer Bianchi |
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Rok vydání: | 2020 |
Předmět: |
Male
medicine.medical_specialty Microbiological culture Old World Tuberculosis Cebinae Microbiology law.invention Mycobacterium tuberculosis 03 medical and health sciences Medical microbiology law Sapajus nigritus Media Technology medicine Animals Lung Polymerase chain reaction 030304 developmental biology 0303 health sciences biology 030306 microbiology biology.organism_classification medicine.disease Virology Veterinary Microbiology - Short Communication Giant cell Sapajus Animals Zoo Lymph Nodes Brazil |
Zdroj: | Braz J Microbiol |
ISSN: | 1678-4405 1517-8382 |
Popis: | Tuberculosis is a common zooanthroponosis in humans with a high incidence in Brazil, but it may also affect non-human primates (NHPs), of which Old World primates are most commonly involved. Nonetheless, its occurrence in New World primates is unknown, and therefore, this study aimed to describe the infection by Mycobacterium tuberculosis variant tuberculosis in two captive black capuchin monkeys (Sapajus nigritus) in Southern Brazil. The primates were housed in the same enclosure, wherein close contact with humans frequently occurred, and presented apathy, anorexia, and death in a clinical course of 15 days to 2 months. At the necropsy, the tracheobronchial lymph nodes were markedly enlarged and firm to hard and on the cut surface had a caseous aspect. The lungs exhibited two injury patterns: multifocal and disseminated. Microscopically, the lungs exhibited multifocal to coalescing necrotic granulomas and non-necrotic granulomas, with multiple acid-fast bacilli within the cytoplasm of epithelioid macrophages and multinucleated giant cells. Bacilli were also labeled upon immunohistochemistry (IHC) for Mycobacterium tuberculosis. Microbiological culture of lung samples from both cases yielded colonies compatible with M. tuberculosis. The isolates were identified as M. tuberculosis var. tuberculosis through polymerase chain reaction (PCR). Although tuberculosis is poorly described in New World primates, M. tuberculosis var. tuberculosis may cause a highly contagious and progressive disease with high mortality in black capuchin monkeys (S. nigritus). |
Databáze: | OpenAIRE |
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