Early local functional changes in the human diabetic retina: a global flash multifocal electroretinogram study
| Autor: | Peter G. Swann, Jenny C. Y. Lung, Henry H. L. Chan |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
medicine.medical_specialty genetic structures media_common.quotation_subject Visual Acuity Retina Contrast Sensitivity Cellular and Molecular Neuroscience Diabetes mellitus Ophthalmology Electroretinography Humans Medicine Contrast (vision) media_common Diabetic Retinopathy medicine.diagnostic_test Diabetic retina business.industry Diabetic retinopathy Middle Aged medicine.disease eye diseases Sensory Systems Retinal adaptation Diabetes Mellitus Type 2 sense organs business Retinal Defect Photic Stimulation Retinopathy |
| Zdroj: | Graefe's Archive for Clinical and Experimental Ophthalmology. 250:1745-1754 |
| ISSN: | 1435-702X 0721-832X |
| DOI: | 10.1007/s00417-012-2010-z |
| Popis: | To investigate early functional changes of local retinal defects in type II diabetic patients using the global flash multifocal electroretinogram (MOFO mfERG). Thirty-eight diabetic patients and 14 age-matched controls were recruited. Nine of the diabetics were free from diabetic retinopathy (DR), while the remainder had mild to moderate non-proliferative diabetic retinopathy. The MOFO mfERG was performed at high (98 %) and low (46 %) contrast levels. MfERG responses were grouped into 35 regions for comparison with DR classification at those locations. Z-scores of the regional mfERG responses were compared across different types of DR defects. The mfERG waveform consisted of the direct component (DC) and the induced component (IC). Local reduction in DC and IC amplitudes were found in diabetic patients with and without DR. With increasing severity of retinopathy, there was a further deterioration in amplitude of both components. Under MOFO mfERG paradigm, amplitude was a useful screening parameter. The MOFO mfERG can help in detecting early functional anomalies before the appearance of visible signs, and may assist in monitoring further functional deterioration in diabetic patients. |
| Databáze: | OpenAIRE |
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