Association of CYP2C8, CYP2C9 and CYP2J2 gene polymorphisms with myocardial infarction in South Indian population
| Autor: | Chandrasekaran Adithan, Ramasamy Kesavan, Annan Sudarsan Arun Kumar, Gurusamy Umamaheswaran, Srinivasamurthy Suresh Kumar, Jayaraman Balachandar |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Heterozygote Genotype medicine.medical_treatment Myocardial Infarction India Cytochrome P-450 CYP2J2 Polymerase Chain Reaction CYP2J2 Cytochrome P-450 CYP2C8 Asian People Cytochrome P-450 Enzyme System Risk Factors Internal medicine Fibrinolysis medicine Humans Myocardial infarction CYP2C8 CYP2C9 Genotyping Cytochrome P-450 CYP2C9 Retrospective Studies Pharmacology Polymorphism Genetic business.industry Retrospective cohort study General Medicine DNA Middle Aged medicine.disease Coronary arteries Endocrinology medicine.anatomical_structure Female Aryl Hydrocarbon Hydroxylases business |
| Zdroj: | Pharmacological reports : PR. 67(1) |
| ISSN: | 2299-5684 |
| Popis: | Background Cardiovascular diseases (CVDs) are the major cause of mortality and morbidity worldwide. Myocardial infarction (MI) is a complex multi-factorial, polygenic disorder arising from an interaction between genetic makeup of individuals and various environmental factors. CYP2C8, CYP2C9 and CYP2J2 gene involved in the metabolism of arachidonic acid, generates epoxyeicosatrienoic acids (EETs) that mediate dilation of coronary arteries improving post-ischemic cardiac contractile function, reduce vascular inflammation, and increase intravascular fibrinolysis. The study is aimed at analyzing the association of CYP2C8, CYP2C9 and CYP2J2 gene polymorphisms and MI risk in the South Indian population. Methods This retrospective study consisted of 287 MI patients, 279 risk control patients and 321 healthy individuals. Blood samples were collected from all the subjects and DNA was isolated using standard phenol–chloroform method. Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) and real time-polymerase chain reaction (RT-PCR) methods were used for genotyping. To test the potential independent association between polymorphisms and the risk of MI, Multiple-logistic regression analysis was performed. Results Our findings displayed a significant association between CYP2J2*7 ( p = 0.04; OR = 2.0) polymorphism and MI while comparing cases with to risk controls. We did not observe any association of CYP2C8*2, CYP2C8*3, CYP2C9*2 and CYP2C9*3 with MI. Conclusion Our results suggest that individuals with any conventional risk factor for MI along with CYP2J2*7 variant allele may be predisposed to risk of MI in South Indian population. |
| Databáze: | OpenAIRE |
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