Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect
| Autor: | Tetsu Machida, Takahiro Nakamura, Daisuke Sato, Myat Nyan, Mitsumasa Oda, Shohei Kasugai, Hiroshi Kobayashi |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Simvastatin Bone Regeneration Time Factors chemistry.chemical_element Bone Morphogenetic Protein 2 Calvaria Inflammation Biocompatible Materials Calcium Bone morphogenetic protein Bone morphogenetic protein 2 Calcium Sulfate Transforming Growth Factor beta Internal medicine medicine polycyclic compounds Animals Rats Wistar Bone regeneration Pharmacology biology Anticholesteremic Agents Skull lcsh:RM1-950 nutritional and metabolic diseases Transforming growth factor beta Rats Drug Combinations Endocrinology medicine.anatomical_structure lcsh:Therapeutics. Pharmacology chemistry Gene Expression Regulation Bone Morphogenetic Proteins Bone Substitutes biology.protein Molecular Medicine lipids (amino acids peptides and proteins) medicine.symptom medicine.drug |
| Zdroj: | Journal of Pharmacological Sciences, Vol 104, Iss 4, Pp 384-386 (2007) |
| ISSN: | 1347-8613 |
| Popis: | Simvastatin, a cholesterol synthesis inhibitor, enhances BMP2 expression in osteoblasts. The purpose of the present study was to examine whether simvastatin stimulates bone regeneration when combined with calcium sulfate as a carrier. Critical-sized bone defects in rat calvaria were treated with calcium sulfate or with combination of 1 mg simvastatin and calcium sulfate. In the combination group, although the least amount of bone formation with intense soft tissue inflammation was observed at 2 and 4 weeks, remarkable bone formation was evident at 8 weeks. Conclusively, the combination of simvastatin and calcium sulfate stimulated bone regeneration in spite of the inflammatory response. Keywords:: simvastatin, calcium sulfate, bone formation |
| Databáze: | OpenAIRE |
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