Rapid Custom Prototyping of Soft Poroelastic Biosensor for Simultaneous Epicardial Recording and Imaging
| Autor: | Chi Hoon Park, Craig J. Goergen, Chi Hwan Lee, Woohyun Park, Bongjoong Kim, Kyunghun Kim, Nevin Stephen Gupta, Haesoo Moon, Arvin H. Soepriatna, Kwan-Soo Lee, Jianchao Zhao, Hanmin Jang, Hyowon Lee, Abigail Cox, Dong Rip Kim, Yale Jeon |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Swine Computer science Myocardial Infarction Silicones General Physics and Astronomy Biocompatible Materials Biosensing Techniques 02 engineering and technology 01 natural sciences Myoblasts Electrocardiography Mice Image Processing Computer-Assisted Ultrasonography Multidisciplinary Prostheses and Implants Direct writing 021001 nanoscience & nanotechnology Ultrasound imaging Ink 0210 nano-technology Biomedical engineering Pericardium Diagnostic Imaging Rapid prototyping 2019-20 coronavirus outbreak Science education Poromechanics Visual feedback Molecular Dynamics Simulation 010402 general chemistry Article General Biochemistry Genetics and Molecular Biology Cell Line Biomaterials Spatio-Temporal Analysis Animals Sensors technology industry and agriculture General Chemistry Biocompatible material Electrophysiological Phenomena 0104 chemical sciences Mice Inbred C57BL Disease Models Animal Biosensor |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021) Nature Communications |
| Popis: | The growing need for the implementation of stretchable biosensors in the body has driven rapid prototyping schemes through the direct ink writing of multidimensional functional architectures. Recent approaches employ biocompatible inks that are dispensable through an automated nozzle injection system. However, their application in medical practices remains challenged in reliable recording due to their viscoelastic nature that yields mechanical and electrical hysteresis under periodic large strains. Herein, we report sponge-like poroelastic silicone composites adaptable for high-precision direct writing of custom-designed stretchable biosensors, which are soft and insensitive to strains. Their unique structural properties yield a robust coupling to living tissues, enabling high-fidelity recording of spatiotemporal electrophysiological activity and real-time ultrasound imaging for visual feedback. In vivo evaluations of custom-fit biosensors in a murine acute myocardial infarction model demonstrate a potential clinical utility in the simultaneous intraoperative recording and imaging on the epicardium, which may guide definitive surgical treatments. Printed biosensors are important for health monitoring and research purposes. Here, the authors report on the development of a soft poroelastic silicone based sensor which can be easily printed and is resistant to mechanical strain hysteresis, allowing for more accurate electrophysiology readings and imaging. |
| Databáze: | OpenAIRE |
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