AR negative triple negative or 'quadruple negative' breast cancers in African American women have an enriched basal and immune signature
| Autor: | William E. Grizzle, Raymond Hughley, Sejong Bae, Lisa A. Newman, Shweta Tripathi, Rachel A. Martini, Balasubramanyam Karanam, Melissa Davis, Clayton Yates, Qinghua He, Windy D. Colomb |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology B Cells lcsh:Medicine Gene Expression Triple Negative Breast Neoplasms Biochemistry White Blood Cells Prostate cancer 0302 clinical medicine Animal Cells Breast Tumors Medicine and Health Sciences CEBPB Ethnicities lcsh:Science African American people Immune Response Triple-negative breast cancer Multidisciplinary Hazard ratio Middle Aged Population groupings Neoplasm Proteins 3. Good health Gene Expression Regulation Neoplastic Receptors Androgen 030220 oncology & carcinogenesis Alabama Immunohistochemistry Female Cellular Types Research Article Adult medicine.medical_specialty Immune Cells Immunology 03 medical and health sciences Breast cancer Diagnostic Medicine Internal medicine Breast Cancer Genetics Cancer Detection and Diagnosis medicine Humans Antibody-Producing Cells Blood Cells business.industry lcsh:R Cancers and Neoplasms Biology and Life Sciences Cell Biology Odds ratio medicine.disease Hormones Black or African American Androgen receptor 030104 developmental biology lcsh:Q People and places business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 13, Iss 6, p e0196909 (2018) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0196909 |
| Popis: | There is increasing evidence that Androgen Receptor (AR) expression has prognostic usefulness in Triple negative breast cancer (TNBC), where tumors that lack AR expression are considered "Quadruple negative" Breast Cancers ("QNBC"). However, a comprehensive analysis of AR expression within all breast cancer subtypes or stratified by race has not been reported. We assessed AR mRNA expression in 925 tumors from The Cancer Genome Atlas (TCGA), and 136 tumors in 2 confirmation sets. AR protein expression was determined by immunohistochemistry in 197 tumors from a multi-institutional cohort, for a total of 1258 patients analyzed. Cox hazard ratios were used to determine correlations to PAM50 breast cancer subtypes, and TNBC subtypes. Overall, AR-negative patients are diagnosed at a younger age compared to AR-positive patients, with the average age of AA AR-negative patients being, 49. AA breast tumors express AR at lower rates compared to Whites, independent of ER and PR expression (p |
| Databáze: | OpenAIRE |
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