Effect of Phosphorylated Tau on Cortical Pyramidal Neuron Morphology during Hibernation
| Autor: | Mamen Regalado-Reyes, Javier DeFelipe, Gonzalo León-Espinosa, Isabel Fernaud-Espinosa, Ruth Benavides-Piccione |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Dendritic spine Syrian hamster dendrites Tau protein Hyperphosphorylation Hippocampal formation 03 medical and health sciences Glutamatergic 0302 clinical medicine Postsynaptic potential medicine 3D reconstructions General Environmental Science biology Chemistry dendritic spines 030104 developmental biology medicine.anatomical_structure Cerebral cortex Excitatory postsynaptic potential biology.protein General Earth and Planetary Sciences cerebral cortex Original Article Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cerebral Cortex Communications |
| ISSN: | 2632-7376 |
| Popis: | The dendritic spines of pyramidal cells are the main postsynaptic target of excitatory glutamatergic synapses. Morphological alterations have been described in hippocampal dendritic spines during hibernation—a state of inactivity and metabolic depression that occurs via a transient neuronal tau hyperphosphorylation. Here, we have used the hibernating Syrian hamster to investigate the effect of hyperphosphorylated tau regarding neocortical neuronal structure. In particular, we examined layer Va pyramidal neurons. Our results indicate that hibernation does not promote significant changes in dendritic spine density. However, tau hyperphosphorylated neurons show a decrease in complexity, an increase in the tortuosity of the apical dendrites, and an increase in the diameter of the basal dendrites. Tau protein hyperphosphorylation and aggregation have been associated with loss or alterations of dendritic spines in neurodegenerative diseases, such as Alzheimer’s disease (AD). Our results may shed light on the correlation between tau hyperphosphorylation and the neuropathological processes in AD. Moreover, we observed changes in the length and area of the apical and basal dendritic spines during hibernation regardless of tau hyperphosphorylation. The morphological changes observed here also suggest region specificity, opening up debate about a possible relationship with the differential brain activity registered in these regions in previous studies. |
| Databáze: | OpenAIRE |
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