Clinicopathological Analysis of Non-B Non-C Hepatocellular Carcinoma Focusing on Cellular Proliferation

Autor:	Shinji, Mizuochi, Jun, Akiba, Reiichiro, Kondo, Hironori, Kusano, Taro, Shioga, Keiichi, Kondo, Kana, Tsutsui, Masamichi, Nakayama, Sachiko, Ogasawara, Yoshiki, Naito, Osamu, Nakashima, Hirohisa, Yano
Rok vydání:	2021
Předmět:	Liver Cirrhosis Male Hepatitis B virus Cancer Research Carcinoma Hepatocellular Liver Neoplasms General Medicine Middle Aged Progression-Free Survival Gene Expression Regulation Neoplastic Ki-67 Antigen Oncology Tissue Array Analysis Humans Female Aged Cell Proliferation
Zdroj:	Anticancer Research. 42:449-457
ISSN:	1791-7530 0250-7005
Popis:	Non-B non-C hepatocellular carcinomas (NBNC-HCCs) are larger than hepatitis virus-related HCCs. We conducted a clinicopathological study of patients who underwent curative NBNC-HCC resection, including proliferative activity assessments, such as nuclear grade and Ki-67 labelling index (LI).Histopathological findings of 197 patients were examined, including 56 NBNC-HCCs, 45 hepatitis B virus (HBV)-related HCCs (HBV-HCC), and 96 hepatitis C virus (HCV)-related HCCs (HCV-HCC).NBNC-HCCs were significantly larger than HCV-HCCs, but not significantly different from HBV-HCCs. Mitotic counts, nuclear grade, and Ki-67 LI of NBNC-HCCs were not significantly different from those of HCV-HCCs, but were significantly lower than those of HBV-HCCs. Recurrence-free survival was significantly better in the NBNC-HCC group than in the HBV-HCC group in cases with mild liver fibrosis.NBNC-HCCs were significantly larger in diameter, but their nuclear grade or Ki-67 LI were not significantly different from those of other HCCs, suggesting that they do not have a higher proliferative activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80bb9a870e1fe364ca43df92492737d https://doi.org/10.21873/anticanres.15503 Zobrazit plný text záznamu