Accuracy of a rapid intrapartum group B Streptococcus test: A new immunochromatographic assay

Autor: R. Bonnet, L. Gibold, Amélie Delabaere, A. Rossi, S Curinier, Denis Gallot, Sylvie Ughetto
Přispěvatelé: Génétique, Reproduction et Développement (GReD ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Retinoids, Development and Developmental Diseases (R2D2), Université d'Auvergne - Clermont-Ferrand I (UdA), CHU Clermont-Ferrand, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne), Service de Gynécologie [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Génétique, Reproduction et Développement - Clermont Auvergne (GReD ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire Clermont Ferrand, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte - Clermont Auvergne (M2iSH), Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne), Service de Gynécologie-Obstétrique, Thérapie guidée par l'image (TGI), Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)-SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Pediatrics
medicine.medical_specialty
Time Factors
[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics
medicine.disease_cause
Polymerase Chain Reaction
Sensitivity and Specificity
Infant
Newborn
Diseases
Group B
Streptococcus agalactiae
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Pregnancy
Single site
Streptococcal Infections
medicine
Humans
Mass Screening
030212 general & internal medicine
Pregnancy Complications
Infectious
reproductive and urinary physiology
ComputingMilieux_MISCELLANEOUS
Immunoassay
Labor
Obstetric
030219 obstetrics & reproductive medicine
medicine.diagnostic_test
Streptococcus
Obstetrics
business.industry
Incidence (epidemiology)
Infant
Newborn
Parturition
Obstetrics and Gynecology
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Molecular biology
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Infectious Disease Transmission
Vertical
3. Good health
Test (assessment)
Early Diagnosis
Prenatal screening
Reproductive Medicine
Vagina
Female
France
business
DIMA
Zdroj: Journal of Gynecology Obstetrics and Human Reproduction
Journal of Gynecology Obstetrics and Human Reproduction, 2017, 46 (5), pp.449-453. ⟨10.1016/j.jogoh.2017.03.010⟩
Journal of Gynecology Obstetrics and Human Reproduction, Elsevier, 2017, 46 (5), pp.449-453. ⟨10.1016/j.jogoh.2017.03.010⟩
ISSN: 2468-7847
Popis: Objectives To decrease the incidence of early-onset group B streptococcal (GBS) disease, a culture-based screening of all pregnant women at 35–37 weeks is recommended. This gold standard test requires 24–72 hours culture. This delay precludes its use for intrapartum screening. This study assesses a new immunoassay, the DIMA test, for identifying GBS-positive patients in the labor ward. Materials and methods This was a prospective observational study of 195 pregnant women presenting with full-term labor at a single site in France between June and August 2012. We assessed the diagnostic accuracy of intrapartum DIMA testing as compared to intrapartum GBS culture and prenatal screening at 35–38 weeks. Results The DIMA test sensitivity and specificity were 57.1% and 83.2%, respectively, as compared to 42.9% and 97% for prenatal culture screening. Conclusion The DIMA test assay is a rapid and inexpensive test for the detection of maternal GBS colonization in the labor ward. Its sensitivity is higher than antepartum culture but its specificity is lower. Its performance was inferior to that reported for rapid polymerase chain reaction assays.
Databáze: OpenAIRE
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