Late onset levodopa responsive Huntington's disease with minimal chorea masquerading as Parkinson plus syndrome
| Autor: | Michele T.M. Hu, Kallol Ray Chaudhuri, Chris Clough, Thomasin C. Andrews, I Reuter, David J. Brooks |
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| Rok vydání: | 2000 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities Pediatrics medicine.medical_specialty Pathology Levodopa Parkinson's disease Short Report Late onset Antiparkinson Agents Diagnosis Differential Trinucleotide Repeats Huntington's disease Chorea mental disorders medicine Humans Aged Parkinson plus syndrome business.industry Parkinsonism Parkinson Disease Middle Aged medicine.disease nervous system diseases Psychiatry and Mental health Huntington Disease Treatment Outcome Female Surgery Neurology (clinical) medicine.symptom Age of onset business Tomography Emission-Computed medicine.drug |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 68:238-241 |
| ISSN: | 0022-3050 |
| DOI: | 10.1136/jnnp.68.2.238 |
| Popis: | Huntington's disease is characterised by hyperkinetic movements, mainly chorea, cognitive dysfunction, and psychiatric abnormalities. Non-dopa responsive parkinsonism occurs in the later stages of choreic disease or as the predominant feature of juvenile patients (Westphal variant). Late onset Huntington's disease presenting as levodopa responsive parkinsonism is rare. A series of four patients with late onset Huntington's disease presenting as levodopa responsive parkinsonism and cardiovascular dysautonomia, initially misdiagnosed as multiple system atrophy (MSA) in three patients, is reported. Levodopa treatment did not unmask significant chorea. These cases suggest the presence of a distinct phenotypic variant of Huntington's disease to be added to the differential diagnosis of other akinetic rigid syndromes. |
| Databáze: | OpenAIRE |
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