Left Ventricular Trabeculations Decrease the Wall Shear Stress and Increase the Intra-Ventricular Pressure Drop in CFD Simulations
| Autor: | Mariano Vázquez, Bruno Paun, Jazmin Aguado-Sierra, Paul A. Iaizzo, Tinen L. Iles, Federica Sacco, Oriol Lehmkuhl, Guillaume Houzeaux, Constantine Butakoff |
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| Přispěvatelé: | Barcelona Supercomputing Center, European Commission, Fundació La Marató de TV3, University of Minnesota, Aguado-Sierra, Jazmin, Aguado-Sierra, Jazmin [0000-0002-9711-3225] |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Materials science
Physiology 0206 medical engineering Left ventricular hemodynamics 02 engineering and technology Computational fluid dynamics Cor--Ventricles 01 natural sciences lcsh:Physiology Physiology (medical) Ventricular remodeling Shear stress medicine 0101 mathematics Original Research Pressure drop lcsh:QP1-981 business.industry Drop (liquid) Enginyeria biomèdica [Àrees temàtiques de la UPC] Trabeculae Blood flow Mechanics 020601 biomedical engineering 3. Good health Vortex 010101 applied mathematics Left ventricular modeling medicine.anatomical_structure Papillary muscles Ventricle Ventricular pressure cardiovascular system business Porosity |
| Zdroj: | UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) Recercat. Dipósit de la Recerca de Catalunya instname Frontiers in Physiology Digital.CSIC. Repositorio Institucional del CSIC Frontiers in Physiology, Vol 9 (2018) |
| Popis: | The aim of the present study is to characterize the hemodynamics of left ventricular (LV) geometries to examine the impact of trabeculae and papillary muscles (PMs) on blood flow using high performance computing (HPC). Five pairs of detailed and smoothed LV endocardium models were reconstructed from high-resolution magnetic resonance images (MRI) of ex-vivo human hearts. The detailed model of one LV pair is characterized only by the PMs and few big trabeculae, to represent state of art level of endocardial detail. The other four detailed models obtained include instead endocardial structures measuring ≥1 mm2 in cross-sectional area. The geometrical characterizations were done using computational fluid dynamics (CFD) simulations with rigid walls and both constant and transient flow inputs on the detailed and smoothed models for comparison. These simulations do not represent a clinical or physiological scenario, but a characterization of the interaction of endocardial structures with blood flow. Steady flow simulations were employed to quantify the pressure drop between the inlet and the outlet of the LVs and the wall shear stress (WSS). Coherent structures were analyzed using the Q-criterion for both constant and transient flow inputs. Our results show that trabeculae and PMs increase the intra-ventricular pressure drop, reduce the WSS and disrupt the dominant single vortex, usually present in the smoothed-endocardium models, generating secondary small vortices. Given that obtaining high resolution anatomical detail is challenging in-vivo, we propose that the effect of trabeculations can be incorporated into smoothed ventricular geometries by adding a porous layer along the LV endocardial wall. Results show that a porous layer of a thickness of 1.2·10−2 m with a porosity of 20 kg/m2 on the smoothed-endocardium ventricle models approximates the pressure drops, vorticities and WSS observed in the detailed models. This paper has been partially funded by CompBioMed project, under H2020-EU.1.4.1.3 European Union’s Horizon 2020 research and innovation programme, grant agreement n◦675451. FS is supported by a grant from Severo Ochoa (n◦SEV-2015-0493-16-4), Spain. CB is supported by a grant from the Fundació La Marató de TV3 (n◦ 20154031), Spain. TI and PI are supported by the Institute of Engineering in Medicine, USA, and the Lillehei Heart Institute, USA. |
| Databáze: | OpenAIRE |
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