The Effects of Intravenous Lipid Emulsion Therapy in the Prevention of Depressive Effects of Propofol on Cardiovascular and Respiratory Systems: An Experimental Animal Study

Autor: Serdar Abut, Halil Alışkan, Rohat Ak, Engin Sümer, Fatih Doğanay, Ozge Onur
Přispěvatelé: Doganay, Fatih, Ak, Rohat, Aliskan, Halil, Abut, Serdar, Sumer, Engin, Onur, Ozge, Eğitim Fakültesi, Doğanay, F., Ak, R., Alışkan, H., Abut, S., Sümer, E., Onur, Ö., Yeditepe Üniversitesi
Jazyk: angličtina
Rok vydání: 2018
Předmět:
PHARMACOKINETICS
medicine.medical_treatment
Blood Pressure
acute toxicity
pharmacology_toxicology
Rats
Sprague-Dawley
0302 clinical medicine
Heart Rate
030202 anesthesiology
Intravenous lipid emulsion
BUPIVACAINE
cardiovascular depression
Propofol
Saline
lcsh:R5-920
RESUSCITATION
INFUSION
Cardiovascular depression
General Medicine
Anesthesia
Rat model
FATTY-ACIDS
Hypotension
medicine.symptom
Respiratory Insufficiency
lcsh:Medicine (General)
INTRALIPID EMULSION
Anesthetics
Intravenous
medicine.drug
Bradycardia
Fat Emulsions
Intravenous
Respiratory rate
PRESSURE
Article
03 medical and health sciences
respiratory depression
Respiratory Rate
Heart rate
medicine
Animals
ELEVATION
intravenous lipid emulsion
propofol
rat model
Acute toxicity
business.industry
Repeated measures design
Cardiorespiratory fitness
Rats
Blood pressure
Respiratory depression
business
030217 neurology & neurosurgery
Zdroj: Medicina
Volume 55
Issue 1
Medicina; Volume 55; Issue 1; Pages: 1
Medicina, Vol 55, Iss 1, p 1 (2018)
Popis: Background and objectives: Although there are several hypotheses about the mechanism of action, intravenous lipid emulsion (ILE) therapy has been shown to be effective in the treatment of toxicities due to local anaesthetics and many lipophilic drugs. In this study, we had hypothesized that ILE therapy might also be effective in preventing mortality and cardiorespiratory depressant effects due to propofol intoxication. Materials and methods: Twenty-eight Sprague-Dawley adult rats were randomly divided into four groups. Saline was administered to the subjects in the control group. The second group was administered propofol (PP group)
the third group was administered ILE (ILE group), and the fourth group was administered propofol and ILE therapy together (ILE+PP group). Systolic blood pressure (SBP), diastolic blood pressure (DBP), respiratory rate (RR), heart rate (HR), and mortality were recorded at 10 time-points during a period of 60 min. A repeated measures linear mixed-effect model with unstructured covariance was used to compare the groups. Results: In the PP group
SBP, DBP, RR, and HR levels declined steadily
and all rats in this group died after the 60-min period. In the ILE+PP group, the initially reduced SBP, DBP, RR, and HR scores increased close to the levels observed in the control group. The SBP, DBP, RR, and HR values in the PP group were significantly lower compared to the other groups (p <
0.01). The mortality rate was 100% (with survival duration of 60 min) for the PP group
however, it was 0% for the remaining three groups. Conclusions: Our results suggest that the untoward effects of propofol including hypotension, bradycardia, and respiratory depression might be prevented with ILE therapy.
Databáze: OpenAIRE
Externí odkaz: