Retardant Effect of Hyperglycemia on the Rise in Plasma Fatty Acids Following Insulin Withdrawal in Man
| Autor: | G.L. Mueller, J. M. Perry, J E Liljenquist, Alan D. Cherrington, David Rabin |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Fatty Acids Nonesterified Biochemistry Endocrinology Glucose infusion Internal medicine medicine Humans Insulin Chemistry Biochemistry (medical) General Medicine Glucagon Kinetics Glucose Somatostatin Hyperglycemia Plasma insulin hormones hormone substitutes and hormone antagonists Plasma ffa |
| Zdroj: | Hormone and Metabolic Research. 13:542-545 |
| ISSN: | 1439-4286 0018-5043 |
| Popis: | The present study was undertaken to examine the influence of hyperglycemia in retarding the rise in circulating FFA noted after acute insulin withdrawal in man. The arterial FFA response to somatostatin administration was measured in the presence of (a) euglycemia and (b) hyperglycemia. In seven normal men who received somatostatin (0.9 mg/h) with euglycemia maintained by exogenous glucose infusion plasma insulin levels fell to levels 4 uU/ml and plasma FFA concentrations rose from 659 +/- 123 to 2057 +/- 268 uEq/l. When somatostatin was infused with hyperglycemia maintained at approximately 230 mg/dl, plasma insulin levels were again maintained at levels 4 uU/ml. Despite similar insulinopenia plasma FFA concentrations rose from 510 +/- 56 to only 1125 +/- 180 uEq/l, significantly less than in the previous protocol (p less than 0.01). These data indicate that hyperglycemia per se significantly attenuates the rise in circulating FFA caused by acute insulin withdrawal in man. |
| Databáze: | OpenAIRE |
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