| Autor: |
Quan, Wan, Yu, Wang, Ming, Yong, PengFei, Hu, Che Ge, Le Liang, Xiang Jun, Yang, Xiao, Zhao, Dan, San, Ting Ting, Bai, La Ga, Tong, Jingbo, Zhai, Ming, Zhao, QingShan, Zhang |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Biomedicine & Pharmacotherapy. 158:114103 |
| ISSN: |
0753-3322 |
| DOI: |
10.1016/j.biopha.2022.114103 |
| Popis: |
Sanwei sandalwood decoction (SWTX) is a classical Chinese medicine formula and clinically effective treatment for coronary heart disease, including myocardial ischemia/reperfusion (I/R) injury. Because the treatment mechanism of SWTX in I/R injury remains obscure, we intended to analyze the potential cardioprotective effects of SWTX in rats with myocardial I/R injury. Our research revealed that SWTX prolonged ventricular conduction time in a dose-dependent manner. While SWTX significantly delayed left ventricular signal conduction velocity, it had no effect on left atrial conduction velocity. Under sinus conditions, low SWTX concentrations reduced left ventricular conduction dispersion, while high concentrations increased conduction dispersion. SWTX also prolonged the QRS interval, APD30/50/90, and ERP. In whole-cell patch clamp experiments on myocytes, Ito and Ikr were inhibited by SWTX. While SWTX had no effect on I |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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