Heracleum dissectum Ledeb. ethanol extract attenuates metabolic syndrome symptoms in high-fat diet-induced obese mice by activating adiponectin/AMPK signaling
| Autor: | Ji Min Shin, Saruul Erdenebileg, Da Seul Jung, Yang-Ju Son, Chu Won Nho |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
AMPK
0301 basic medicine medicine.medical_specialty Medicine (miscellaneous) Adipose tissue 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Insulin resistance Internal medicine Hyperlipidemia medicine TX341-641 Heracleum dissectum Ledeb 030109 nutrition & dietetics Nutrition and Dietetics Adiponectin Triglyceride Nutrition. Foods and food supply business.industry 04 agricultural and veterinary sciences medicine.disease Metabolic syndrome 040401 food science Obesity Endocrinology chemistry Energy expenditure business Food Science |
| Zdroj: | Journal of Functional Foods, Vol 84, Iss, Pp 104581-(2021) |
| ISSN: | 1756-4646 |
| Popis: | The incidence of obesity has increased worldwide, leading to metabolic disorders such as hyperlipidemia and insulin resistance. Therefore, novel functional foods and therapeutic agents against obesity-related metabolic disorders are needed. We explored the effectiveness of the edible herb Heracleum dissectum Ledeb. (HD) against metabolic syndrome symptoms in a high-fat diet (60% of kcal) obesity mouse model. Metabolic syndrome was induced after 8 weeks of high-fat diet feeding, and HD extract (50 mg/kg) was administered by oral gavage during feeding. HD extract effectively decreased body weight gain and ameliorated the serum lipid status. HD extract also upregulated adiponectin/AMP-activated protein kinase (AMPK) signaling, and had anti-oxidation, anti-inflammation, and anti-insulin resistance effects. HD extract further elevated phosphorylation of AMPK and mitochondria biogenesis in the adipose tissue, resulting increased energy expenditure via the triglyceride/fatty acid cycle. Thus, HD extract could be considered a multi-targeting functional food candidate with novel molecular mechanisms. |
| Databáze: | OpenAIRE |
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