Study protocol of the PEruvian Registry of ST-segment Elevation Myocardial Infarction II (PERSTEMI-II) study

Autor: Guido Bendezu-Quispe, Manuel Chacón-Díaz, Akram Hernández-Vásquez, Rodrigo Vargas-Fernández
Jazyk: angličtina
Rok vydání: 2021
Předmět:
medicine.medical_specialty
Acute coronary syndrome
Physiology
Epidemiology
Science
Cardiology
Myocardial Infarction
Kaplan-Meier Estimate
Cardiovascular Medicine
Geographical locations
Study Protocol
Electrocardiography
Medical Conditions
Peru
medicine
Medicine and Health Sciences
Humans
Hospital Mortality
Prospective Studies
Registries
Cardiovascular Disease Epidemiology
Cause of death
Multidisciplinary
business.industry
Mortality rate
Medical record
Public health
Biology and Life Sciences
South America
Cardiovascular Disease Risk
medicine.disease
Hospitals
Health Care
Health Care Facilities
Cardiovascular Diseases
Research Design
Relative risk
Emergency medicine
Reperfusion
Medicine
ST Elevation Myocardial Infarction
Observational study
People and places
business
Physiological Processes
Follow-Up Studies
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257618 (2021)
ISSN: 1932-6203
Popis: BackgroundMyocardial infarction (MI) is the most prevalent cardiovascular disease globally and is considered a public health problem. In Peru, MI is the second leading cause of death at the national level, with a mortality rate that exceeds 10% in the hospital setting. The study aims to determine the clinical and epidemiological characteristics of ST-segment elevation myocardial infarction (STEMI) in tertiary care facilities belonging to the Peruvian public health system.Methods and analysisThis will be a prospective, observational, multicenter study, with baseline and two follow-up assessments: at admission to the health service, and 30 days and 12 months after admission. This multicenter study will be conducted in 27 hospitals located in the main cities of Peru. The patients included in the study will be over 18 years of age, of either sex, and will have been admitted to the health facility with a diagnosis of acute coronary syndrome with ST-segment elevation. The Kaplan-Meier method will be used to estimate the cumulative in-hospital mortality of patients at 30 days and 12 months of follow-up, and the log-rank test will be used to evaluate the differences between the survival curves between reperfused and non-reperfused patients. Subsequently, to evaluate the risk factors for successful reperfusion and cardiovascular adverse events, generalized linear models of the binomial family with log link function will be used to estimate the bivariate and multivariate relative risk (RR) with their respective 95% confidence intervals. This project was approved by the Ethics and Research Committee of the National Cardiovascular Institute (Instituto Nacional Cardiovascular “Carlos Alberto Peschiera Carrillo”—INCOR [in Spanish]; Approval report 21/2019-CEI).DiscussionAmong the strengths, the observational design will allow the inclusion of a large sample of patients, which will significantly contribute to the knowledge base on STEMI in Peru. It should be noted that this study is the first to examine the clinical-epidemiological characteristics of STEMI in high-resolution hospital centers in Peru with follow-up one year after the event, providing knowledge of these observable characteristics in daily clinical routine. Likewise, the multicenter nature of the study will increase the external validity of the findings. In terms of limitations, the observational design of the study can only describe associations and not causality. Furthermore, since data from medical records will be used, there could be imprecision in the data.
Databáze: OpenAIRE
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