The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages
| Autor: | Luitpold E. Miller, Hans-Peter Jüsten, Rainer H. Straub, J Schölmerich |
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| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Sympathetic nervous system Sympathetic Nervous System Knee Joint Sensory Receptor Cells medicine.medical_treatment Substance P Inflammation Osteoarthritis Biochemistry Arthritis Rheumatoid chemistry.chemical_compound Norepinephrine Nerve Fibers Internal medicine Genetics medicine Humans Arthroplasty Replacement Knee Molecular Biology Aged Aged 80 and over business.industry Macrophages Synovial Membrane Middle Aged medicine.disease Electric Stimulation medicine.anatomical_structure Endocrinology Cytokine chemistry Rheumatoid arthritis Chronic Disease Cytokines Synovial membrane medicine.symptom business Biotechnology Sensory nerve |
| Zdroj: | FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 14(13) |
| ISSN: | 0892-6638 |
| Popis: | Our objective was to investigate sympathetic and sensory nerve fibers in synovial tissue in rheumatoid arthritis (RA) and osteoarthritis (OA) in relation to histological inflammation and synovial cytokine and norepinephrine (NE) secretion. Immunohistochemistry was used to detect nerve fibers and inflammatory parameters. A superfusion technique of synovial tissue pieces was used to investigate cytokine and NE secretion. In RA, we detected 0.2 +/- 0.04 tyrosine hydroxylase-positive (TH-positive=sympathetic) nerve fibers/mm2 as compared to 4.4 +/- 0. 8 nerve fibers/mm2 in OA (P |
| Databáze: | OpenAIRE |
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