Autism spectrum disorder (ASD)-associated mitochondrial deficits are revealed in children's platelets but unimproved by hyperbaric oxygen therapy

Autor:	Mahmoud Aboulsaoud, Sameh S. Ali, Engy A. Abdel-Rahman, Eman Ahmed Zaky, Reham M. Elhossiny, Walaa Y. Youssef, Ali M. Mahmoud
Rok vydání:	2021
Předmět:	0301 basic medicine Blood Platelets Male Mitochondrial Diseases genetic structures Autism Spectrum Disorder macromolecular substances behavioral disciplines and activities Biochemistry 03 medical and health sciences Hyperbaric oxygen Immune system mental disorders Medicine Humans Platelet Child Hyperbaric Oxygenation NADPH oxidase 030102 biochemistry & molecular biology biology business.industry General Medicine medicine.disease Mitochondria 030104 developmental biology Autism spectrum disorder Case-Control Studies Child Preschool Immunology biology.protein Etiology business
Zdroj:	Free radical research. 55(1)
ISSN:	1029-2470
Popis:	Mitochondrial and immune dysfunctions are often implicated in the aetiology of autism spectrum disorder (ASD). Here, we studied for the first time the relationship between ASD severity measures and mitochondrial respiratory rates in freshly isolated platelets as well as the activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) in isolated neutrophils. We also verified the impact of hyperbaric oxygen therapy (HBOT) on mitochondrial and immune functions as well as on ASD severity measures. Blood samples were collected from three age-matched male groups (Control (Norm-N), autistic (Aut-N), and autistic + HBOT (Aut-H)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fbe85a3c4e004f43c217578118a60c https://pubmed.ncbi.nlm.nih.gov/33402007 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.