KLINEFELTER'S SYNDROME: A STUDY OF 5 CASES: HISTOPHYSIOLOGIC BASIS FOR A PATHOGENIC INTERPRETATION*
| Autor: | F. A. De La Balze, J. Irazu, R. E. Mancini, Francisco Arrillaga |
|---|---|
| Rok vydání: | 1952 |
| Předmět: |
Azoospermia
endocrine system medicine.medical_specialty S syndrome endocrine system diseases urogenital system Endocrinology Diabetes and Metabolism Urinary system Biochemistry (medical) Clinical Biochemistry Semen Biology medicine.disease Sertoli cell Biochemistry Klinefelter Syndrome Endocrinology medicine.anatomical_structure Gynecomastia Internal medicine Scrotum medicine Humans Hyaline |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 12:1426-1444 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-12-11-1426 |
| Popis: | KLINEFELTER, Reifenstein and Albright (1) were the first to describe this syndrome of testicular deficiency, which apparently starts at puberty and involves the whole testis. The chief clinical, humoral and histologic characteristics which they noted were: 1) small testes, the size of a chickpea or medium-sized grape, localized in a normally developed scrotum; 2) onset at puberty; 3) azoospermia, or very few spermatozoa present in the semen; 4) an increase in the urinary excretion of hypophyseal gonadotropins; 5) a testicular histologic pattern which shows disappearance of the germ cells (few spermatogonia can be seen), hyalinization of the tubules and morphologic alterations of the Leydig and Sertoli cells; 6) gynecomastia appearing at puberty; 7) usually a reduction in the urinary excretion of neutral 17-ketosteroids, although in some cases it is normal; and 8) usually no clinical manifestations of androgenic deficiency. Later, Heller and Nelson (2) demonstrated in similar cases that gynecomastia is not... |
| Databáze: | OpenAIRE |
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