Is cell transplantation a reliable therapeutic strategy for spinal cord injury in clinical practice? A systematic review and meta-analysis from 22 clinical controlled trials

Autor: Yu-Shan Gao, Xiumei Wang, Li-Jun Duan, Yang Xiong, Xing Yu, Qing-Ling Sun, Jia-Wei Song, Ding-Yan Zhao, He-Jun Wang, Kaitan Yang, He Zhao, Yongdong Yang
Rok vydání: 2019
Předmět:
Zdroj: European Spine Journal. 28:1092-1112
ISSN: 1432-0932
0940-6719
DOI: 10.1007/s00586-019-05882-w
Popis: It is an open question whether cell transplantation can provide safety and effective outcome to spinal cord injury (SCI) patient which has remained controversial for almost 40 years. This study aimed to evaluate the safety and efficacy of cell transplantation in SCI patients.Studies of the cell transplantation for SCI were retrieved from PubMed, Embase, Medline, Cochrane Library and analyzed quantitative data by Review Manager 5.3.Twenty-one clinical controlled studies with 973 patients were included. The pooled results suggested that cell transplantation significantly improved ASIA score, ASIA motor score, ASIA sensory score, Barthel Index score, residual urine volume, rehabilitative time of automatic micturition. Furthermore, subgroup analysis indicated that the stem cells exhibited more potent than the non-stem cells in spinal cord repair. Cell transplantation at more than 14 days after injury showed more significant improvements than that within 14 days from injury. The dosage of cell transplantation between 1-5 × 10Cell transplantation appears to be a safe therapeutic strategy possessing substantial beneficial effects in the patients with SCI in clinic. Moreover, treating SCI with stem cell, the dosage of cells between 1-5 × 10
Databáze: OpenAIRE
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