Progesterone, Lipoic Acid, and Sulforaphane as Promising Antioxidants for Retinal Diseases: A Review
| Autor: | Inmaculada Almansa, Vicente Hernández-Rabaza, Rosa López-Pedrajas |
|---|---|
| Přispěvatelé: | UCH. Departamento de Ciencias Biomédicas, Producción Científica UCH 2019 |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Antioxidant Physiology medicine.medical_treatment Clinical Biochemistry sulforaphane Review Pharmacology Progesterona - Uso terapéutico medicine.disease_cause Biochemistry chemistry.chemical_compound 0302 clinical medicine Retina - Diseases - Risk factors Ácido lipoico - Uso terapéutico reactive oxygen species Sulforaphane - Therapeutic use Retina - Diseases - Treatment Lipoic acid retinal diseases antioxidants Antioxidantes macular degeneration progesterone Neuroprotection Progesterone - Therapeutic use 03 medical and health sciences retinitis pigmentosa Retinitis pigmentosa medicine Retina - Enfermedades - Factores de riesgo Molecular Biology business.industry lcsh:RM1-950 Retinal Cell Biology Macular degeneration medicine.disease lipoic acid Lipoic acid - Therapeutic use 030104 developmental biology lcsh:Therapeutics. Pharmacology chemistry 030221 ophthalmology & optometry business Antioxidants diabetes retinopathy Sulforafano - Uso terapéutico Oxidative stress Sulforaphane Retina - Enfermedades - Tratamiento |
| Zdroj: | Antioxidants Antioxidants, Vol 8, Iss 3, p 53 (2019) CEU Repositorio Institucional Fundación Universitaria San Pablo CEU (FUSPCEU) |
| ISSN: | 2076-3921 |
| Popis: | Este artículo se ha publicado de forma definitiva en: https://www.mdpi.com/2076-3921/8/3/53 Este artículo pertenece al número especial "Antioxidants and Retinal Disease". Oxidative stress has been documented to be a key factor in the cause and progression of different retinal diseases. Oxidative cellular unbalance triggers a sequence of reactions which prompt cell degeneration and retinal dysfunction, both hallmarks of several retinal pathologies. There is no effective treatment, yet, for many retinal diseases. Antioxidant treatment have been pointed out to be an encouraging palliative treatment; the beneficial effects documented involve slowing the progression of the disease, a reduction of cell degeneration, and improvement of retinal functions. There is a vast information corpus on antioxidant candidates. In this review, we expose three of the main antioxidant treatments, selected for their promising results that has been reported to date. Recently, the sulforaphane, an isothiocyanate molecule, has been unveiled as a neuroprotective candidate, by its antioxidant properties. Progesterone, a neurosteroid has been proposed to be a solid and effective neuroprotective agent. Finally, the lipoic acid, an organosulfur compound, is a well-recognized antioxidant. All of them, have been tested and studied on different retinal disease models. In this review, we summarized the published results of these works, to offer a general view of the current antioxidant treatment advances, including the main effects and mechanisms described. |
| Databáze: | OpenAIRE |
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