Cervical cancer systemic inflammation score: a novel predictor of prognosis
| Autor: | Lin-chai Zeng, Min Huang, Feng Lin, Chu Jin, Han-chu Wang, Fei-yun Zheng, Ru-ru Zheng, Jiang-tao Yu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Neutrophils cervical cancer overall survival Serum albumin Uterine Cervical Neoplasms Inflammation Systemic inflammation 03 medical and health sciences 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Overall survival Humans Lymphocytes disease free survival Survival rate albumin Retrospective Studies Cervical cancer biology business.industry platelet to lymphocyte ratio Retrospective cohort study Middle Aged Prognosis medicine.disease Surgery Survival Rate 030104 developmental biology 030220 oncology & carcinogenesis Risk stratification biology.protein Female Clinical Research Paper medicine.symptom business Follow-Up Studies |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Inflammation contributes to development and progression in a variety of cancers, including cervical cancer. We developed a novel cervical cancer systemic inflammation score (CCSIS) based on the preoperative platelet-to-lymphocyte ratio (PLR) and serum albumin levels. A retrospective analysis of clinical data from 795 patients with operable cervical cancer was then conducted to investigate the prognostic value of CCSIS and its association with the patients' clinicopathological features, overall survival (OS), and disease-free survival (DFS). CCSIS was predictive of OS and DFS. High CCSIS was correlated with more advanced FIGO stages, poor tumor differentiation, and the presence of PLN and LVSI. Both albumin levels and the PLR were independent prognostic indicators for operable cervical cancer. The use of the CCSIS could improve risk stratification and traditional clinicopathological analysis in cervical cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|