Standard partition coefficients of anionic drugs in the n-octanol/water system determined by voltammetry at three-phase electrodes

Autor:	Rubin Gulaboski, Fritz Scholz, Géraldine Bouchard, Hubert H. Girault, Pierre-Alain Carrupt, Valentin Mirčeski, Alexandra Galland
Rok vydání:	2003
Předmět:	Octanol ddc:615 Chemistry Inorganic chemistry Solvation General Physics and Astronomy Electrochemistry Ion Basic medicine Physical sciences Partition coefficient Biological sciences chemistry.chemical_compound Chemical sciences Lipophilicity Electrode Physical and Theoretical Chemistry Voltammetry
Zdroj:	Physical Chemistry Chemical Physics, Vol. 5, No 17 (2003) pp. 3748-3751
ISSN:	1463-9084 1463-9076
Popis:	The anionic forms of 26 drugs and organic model compounds have been extensively explored in the n-octanol/ water system using voltammetry at three-phase electrodes. The objective of this study was to validate the ability of this electrochemical system to give reliable values of lipophilicity for organic ions, as well as to gain more information on the lipophilic behaviour of anions in the n-octanol/water system. Results were used to clarify the solvation mechanisms responsible for ion partitioning and to compare the information obtained in the two solvent systems n-octanol/water and 1,2-dichloroethane/water.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f7a960ba1c2a662cc8a194091a998d https://doi.org/10.1039/b304113a Zobrazit plný text záznamu