Hydrocortisone decreases metacognitive efficiency independent of perceived stress

Autor: Jérôme Sackur, Carolina Manosalva, Jaime R. Silva, Franco Medina, Anastassia Vivanco-Carlevari, Gabriel Reyes, Vincent de Gardelle
Přispěvatelé: Facultad de Psicología, Universidad del Desarrollo (UDD) [Chile], Faculty of Sciences, Universidad Austral de Chile (UACh) [Chile], Centre National de la Recherche Scientifique (CNRS), Paris School of Economics (PSE), École des Ponts ParisTech (ENPC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS)-École des hautes études en sciences sociales (EHESS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre d'économie de la Sorbonne (CES), Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de sciences cognitives et psycholinguistique (LSCP), Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL), Département d'Humanités et Sciences Sociales de l'École polytechnique (X-DEP-HSS), École polytechnique (X), Clinica Alemana de Santiago, Instituto Milenio para la Investigación en Depresión y Personalidad [Chile] (MIDAP), This research was supported by FONDECYT MetaDynamic [N° 11170775, GR], FONDECYT MetaStress [N° 1171836, JRS and GR], FONDECYT Meta3C [N° 1191708, JRS and GR], MetaStress [ANR-16-ASTR-0014, JS and VdG, ANR-10-LABX-0087 IEC and ANR-10-IDEX-0001-02 PSL, JS], and by the FIC, Millennium Scientific Initiative [N° IS130005, JRS]., ANR-16-ASTR-0014,MetaStress,Impact du stress sur la décision et la métacognition: applications en aéronautique(2016), ANR-10-IDEX-0001,PSL,Paris Sciences et Lettres(2010)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.14100. ⟨10.1038/s41598-020-71061-3⟩
ISSN: 2045-2322
DOI: 10.1038/s41598-020-71061-3
Popis: It is well established that acute stress produces negative effects on high level cognitive functions. However, these effects could be due to the physiological components of the stress response (among which cortisol secretion is prominent), to its psychological concomitants (the thoughts generated by the stressor) or to any combination of those. Our study shows for the first time that the typical cortisol response to stress is sufficient to impair metacognition, that is the ability to monitor one’s own performance in a task. In a pharmacological protocol, we administered either 20 mg hydrocortisone or placebo to 46 male participants, and measured their subjective perception of stress, their performance in a perceptual task, and their metacognitive ability. We found that hydrocortisone selectively impaired metacognitive ability, without affecting task performance or creating a subjective state of stress. In other words, the single physiological response of stress produces a net effect on metacognition. These results inform our basic understanding of the physiological bases of metacognition. They are also relevant for applied or clinical research about situations involving stress, anxiety, depression, or simply cortisol use.
Databáze: OpenAIRE
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