Platelet-rich plasma and macular hole surgery: A clue to their mode of action and the influence of anti-platelet agents
| Autor: | Francesco Maria D’Alterio, Mariantonia Ferrara, Alan Bagnall, Kate L Talks, Roxane J Hillier |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | European Journal of Ophthalmology. :112067212210936 |
| ISSN: | 1724-6016 1120-6721 |
| Popis: | Purpose To present a case of refractory full-thickness macular hole (FTMH), in which autologous platelet-rich plasma (aPRP) was used on two consecutive occasions, and associated with successful closure only after complete cessation of anti-platelet therapy. Methods Interventional case report. Results A 63-year-old male with Alport syndrome underwent pars plana vitrectomy with internal limiting membrane peeling and gas for a large FTMH. The patient was on systemic anti-platelet agents for coronary disease. Post-operatively, the FTMH remained open and repeated surgery, augmented with aPRP, was performed. Although a thick pre-retinal coagulum was evident on optical coherence tomography on day one post-surgery, the second surgery failed. Ultimately, successful aPRP-augmented surgical closure of the FTMH was achieved only after complete cessation of systemic anti-platelet agents. Conclusion Appropriate management of anti-platelet therapy may be relevant when planning aPRP use, though further large-scale studies are needed to assess the precise effect of anti-platelet therapy on the efficacy of aPRP, and to confirm the potential role of aPRP in patients with Alport syndrome. |
| Databáze: | OpenAIRE |
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