The origin, fate, and contribution of macrophages to spinal cord injury pathology
| Autor: | Jae K. Lee, Christine B. Ryan, Lindsay M. Milich |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Macrophage polarization Inflammation Biology Article Pathology and Forensic Medicine 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine medicine Animals Humans Macrophage Spinal cord injury Spinal Cord Injuries Microglia Macrophages Regeneration (biology) medicine.disease 030104 developmental biology medicine.anatomical_structure Immunology Neurology (clinical) Bone marrow medicine.symptom Wound healing 030217 neurology & neurosurgery |
| Zdroj: | Acta Neuropathol |
| ISSN: | 1432-0533 0001-6322 |
| DOI: | 10.1007/s00401-019-01992-3 |
| Popis: | Virtually all phases of spinal cord injury pathogenesis, including inflammation, cell proliferation and differentiation, as well as tissue remodeling, are mediated in part by infiltrating monocyte-derived macrophages. It is now clear that these infiltrating macrophages have distinct functions from resident microglia and are capable of mediating both harmful and beneficial effects after injury. These divergent effects have been largely attributed to environmental cues, such as specific cytokines, that influence the macrophage polarization state. In this review, we also consider the possibility that different macrophage origins, including the spleen, bone marrow, and local self-renewal, may also affect macrophage fate, and ultimately their function that contribute to the complex pathobiology of spinal cord injury. |
| Databáze: | OpenAIRE |
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