The investigation of antioxidant and anti-inflammatory potentials of apitherapeutic agents on heart tissues in nitric oxide synthase inhibited rats via Nω-nitro-L-arginine methyl ester

Autor: Betul Ozdemir, Engin Sahna, Zeliha Selamoglu, Mehmet Fuat Gulhan
Přispěvatelé: Teknik Bilimler Meslek Yüksekokulu
Rok vydání: 2020
Předmět:
Male
Antioxidant
Physiology
medicine.medical_treatment
Anti-Inflammatory Agents
Blood Pressure
030204 cardiovascular system & hematology
Pharmacology
medicine.disease_cause
Antioxidants
Pathogenesis
Rats
Sprague-Dawley
chemistry.chemical_compound
0302 clinical medicine
Caffeic acid
030212 general & internal medicine
biology
Chemistry
NF-kappa B
food and beverages
Heart
General Medicine
Free Radical Scavengers
Anti-inflammatory Effect
Phenylethyl Alcohol
Oxidants
Nitric oxide synthase
NG-Nitroarginine Methyl Ester
Pollen
hypertension
medicine.drug_class
Arginine
Anti-inflammatory
Propolis
03 medical and health sciences
Caffeic Acids
Internal Medicine
medicine
Animals
Aryldialkylphosphatase
Myocardium
Apitheraphy
Rats
Oxidative Stress
Blood pressure
biology.protein
Rat
Nitric Oxide Synthase
Oxidative stress
Zdroj: Clinical and experimental hypertension (New York, N.Y. : 1993). 43(1)
ISSN: 1525-6006
Popis: Gülhan, Mehmet Fuat ( Aksaray, Yazar )
Background: High blood pressure effects heart and vessels. Development of pathogenesis is the result of oxidative stress. We aimed to investigate the antioxidant effects of propolis, caffeic acid phenethyl ester (CAPE), and pollen on the hearts of rats which chronic nitric oxide synthase (NOS) inhibited through Nω-nitro-L-arginine methyl ester (L-NAME). Paraoxonase 1 (PON1), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), asymmetric dimethylarginine (ADMA), and nuclear factor-κB (NF-κB) were analyzed on the heart. Material and Methods: Sprague-Dawley rats were divided five groups of seven rats in every group; Group I: Control, Group II: L-NAME, Group III: L-NAME+propolis, Group IV: L-NAME+CAPE and Group V: L-NAME+pollen. L-NAME become dissolved in regular saline (0.9% NaCl w/v). The ethanolic extract of propolis (200 mg/kg/days, gavage), pollen (100 mg/kg/days, by gavage), CAPE (50 µM/kg/days, intraperitoneally), and the NOS inhibitor L-NAME (40 mg/kg, intraperitoneally) had been administered. Results: Blood pressure (BP) of rats treated with propolis, CAP,E and pollen statistically significant decreased. Decreasing in BP of the rats of pollen group was more than CAPE and propolis groups (P < .05). PON1 and TAS levels decreased in L-NAME-treated groups (P < .05), but ranges have been better in propolis, CAPE and pollen groups. TOS, ADMA and NF-κB levels increased (P < .05) in L-NAME group; however, these parameters were lower (P < .05) in propolis and CAPE groups (P < .05). Conclusions: Vasorelaxant properties and free radical scavenging actions of propolis, CAPE, and pollen may reduce the oxidative stress and blood pressure in the rats chronic NOS inhibited through L-NAME.
Databáze: OpenAIRE
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