Cutaneous Hemorrhage Types as Supportive Factors for Predicting Chronic Immune Thrombocytopenia in Children
| Autor: | Yaakov Schachter, Sarit Kalfon, Nechama Sharon, Haitham Hamadeh |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent MEDLINE Hemorrhage Single Center Skin Diseases 03 medical and health sciences 0302 clinical medicine immune system diseases Risk Factors hemic and lymphatic diseases 030225 pediatrics Medicine Humans Child Retrospective Studies Purpura Thrombocytopenic Idiopathic business.industry Retrospective cohort study Hematology Prognosis Immune thrombocytopenia Clinical trial Purpura Chronic disease Oncology 030220 oncology & carcinogenesis Child Preschool Pediatrics Perinatology and Child Health Chronic Disease Female Presentation (obstetrics) medicine.symptom business |
| Zdroj: | Journal of pediatric hematology/oncology. 40(5) |
| ISSN: | 1536-3678 |
| Popis: | Our objective was to assess risk factors for developing chronic immune thrombocytopenia (ITP) in children. The charts of all consecutive children diagnosed with ITP between 2000 and 2015 at a single center were retrospectively reviewed, and clinical characteristics at initial presentation were analyzed. Sixty-two children were included in the study (mean age, 6.15 y); 44 (71%) were found to have acute ITP, and 18 (29%) developed chronic ITP (permanent or relapsing thrombocytopenia12 mo). In a univariate analysis, cutaneous hemorrhages were observed significantly more in acute patients (90.9%) than in chronic patients (61.1%). Patients who had acute ITP were more likely to present with a combination of petechiae, purpura, and/or ecchymosis (75%) than patients with chronic disease (44.4%, P=0.010). In multivariate analysis, older age increased the risk (odds ratio=1.1; P0.05) for chronic disease, and manifestations of combination skin hemorrhages (petechiae/purpura/ecchymosis) reduced the risk (odds ratio=0.167; P0.05). In conclusion, the most important risk factor for chronic disease is older age. Skin hemorrhage types were found to be a supportive factor for the prediction process: the combination of petechia/purpura/ecchymosis was associated with a lower risk for developing chronic disease compared with petechiae alone. Future studies should assess the prognostic value of skin hemorrhage types that are a simple way to predict the course of ITP in children. |
| Databáze: | OpenAIRE |
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