Yeast proteomics and protein microarrays
| Autor: | Rui Chen, Michael Snyder |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Genetics
Proteomics medicine.medical_specialty biology ved/biology Systems biology Saccharomyces cerevisiae ved/biology.organism_classification_rank.species Biophysics Protein Array Analysis Computational biology biology.organism_classification Biochemistry Genome Yeast Article Fungal Proteins Molecular genetics Yeasts Protein microarray medicine Humans Model organism |
| Zdroj: | Journal of Proteomics |
| ISSN: | 1874-3919 |
| DOI: | 10.1016/j.jprot.2010.08.003 |
| Popis: | Our understanding of biological processes as well as human diseases has improved greatly thanks to studies on model organisms such as yeast. The power of scientific approaches with yeast lies in its relatively simple genome, its facile classical and molecular genetics, as well as the evolutionary conservation of many basic biological mechanisms. However, even in this simple model organism, systems biology studies, especially proteomic studies had been an intimidating task. During the past decade, powerful high-throughput technologies in proteomic research have been developed for yeast including protein microarray technology. The protein microarray technology allows the interrogation of protein-protein, protein-DNA, protein-small molecule interaction networks as well as post-translational modification networks in a large-scale, high-throughput manner. With this technology, many groundbreaking findings have been established in studies with the budding yeast Saccharomyces cerevisiae, most of which could have been unachievable with traditional approaches. Discovery of these networks has profound impact on explicating biological processes with a proteomic point of view, which may lead to a better understanding of normal biological phenomena as well as various human diseases. |
| Databáze: | OpenAIRE |
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