Simple access to β-trifluoromethyl-substituted ketones via copper-catalyzed ring-opening trifluoromethylation of substituted cyclopropanols
| Autor: | Dzmitry G. Kananovich, Yulia A. Konik, Dzmitry M. Zubrytski, Margus Lopp, Ivar Järving |
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| Rok vydání: | 2015 |
| Předmět: |
Trifluoromethyl
Alkylation Trifluoromethylation Metals and Alloys General Chemistry Ketones Ring (chemistry) Medicinal chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound chemistry Ethers Cyclic Reagent Yield (chemistry) Materials Chemistry Ceramics and Composites Organic chemistry Methanol Copper |
| Zdroj: | Chemical communications (Cambridge, England). 51(39) |
| ISSN: | 1364-548X |
| Popis: | Tertiary cyclopropanols react rapidly with Togni reagent in methanol at room temperature in the presence of catalytic amounts (3 mol%) of CuCl affording β-trifluoromethyl ketones in 65–73% isolated yields. Ring opening in 1,2-dialkylsubstituted cyclopropanols gives a mixture of isomeric β-trifluoromethyl ketones in about 50% combined yield. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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