Penicillin G as a novel chiral selector in capillary electrophoresis
| Autor: | Jung Hag Park, Shuchi Dixit |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Penicillin G Potassium
Pyrrolidines Electrolyte Citalopram Biochemistry Analytical Chemistry chemistry.chemical_compound Capillary electrophoresis Sertraline medicine Solubility Acetonitrile Benzofurans Chromatography Methanol Organic Chemistry Temperature Electrophoresis Capillary Penicillin G Stereoisomerism General Medicine Hydrogen-Ion Concentration Propranolol Anti-Bacterial Agents Penicillin chemistry Enantiomer Metoprolol medicine.drug |
| Zdroj: | Journal of Chromatography A. 1326:134-138 |
| ISSN: | 0021-9673 |
| DOI: | 10.1016/j.chroma.2013.12.018 |
| Popis: | The penicillin sub-class of β-lactam antibiotics has not been examined for its enantiodiscriminating abilities in capillary electrophoresis (CE) until date. The present work was therefore designed to evaluate penicillin G potassium salt (PenG) as an ion-pair chiral selector (CS) using CE for its several attributes, namely, high solubility in water and lower alcohols, structure allowing multiple interactions with analytes and cost-effectiveness. Systematic experiments were performed to investigate the effect of composition of background electrolyte, applied voltage and capillary temperature on chiral separation. Baseline resolutions of enantiomers of five basic chiral drugs (namely, darifenacin, citalopram, sertraline, propranolol and metoprolol) were attained using a background electrolyte composed of water:methanol (90:10, v/v) and consisting of 10.7 or 16.1mM CS at 20°C using an applied voltage of 5kV. |
| Databáze: | OpenAIRE |
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