Therapeutic targeting of malignant glioma
| Autor: | Daniela A. Bota, Martin R. Jadus, Apostolos Stathopoulos, Daniela Alexandru-Abrams, Frank P.K. Hsu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
Drug Resistance Bioinformatics chemotherapy Stem Cell Research - Nonembryonic - Human Cell Movement Cancer Tumor Brain Neoplasms Cell Differentiation Local Neoplastic Stem Cells Molecular Medicine Stem Cell Research - Nonembryonic - Non-Human Hypoxia-Inducible Factor 1 immunotherapy Stem cell Signal transduction Signal Transduction endocrine system Medicinal & Biomolecular Chemistry Oncology and Carcinogenesis Brain tumor Antineoplastic Agents Biology Glioma cell Therapeutic targeting alpha Subunit treatment resistance Immunomodulation Medicinal and Biomolecular Chemistry Rare Diseases Glioma medicine Biomarkers Tumor Animals Humans Neoplasm Invasiveness Cell Proliferation Pharmacology Neurosciences malignant glioma medicine.disease Stem Cell Research Hypoxia-Inducible Factor 1 alpha Subunit Brain Disorders Brain Cancer MicroRNAs Neoplasm Recurrence Drug Resistance Neoplasm Cancer research glioma stem cells Neoplasm Neoplasm Recurrence Local Glioblastoma Biomarkers |
| Zdroj: | Alexandru-Abrams, D; Jadus, MR; Hsu, FP; Stathopoulos, A; & Bota, DA. (2014). Therapeutic targeting of malignant glioma. Anti-Cancer Agents in Medicinal Chemistry, 14(8), 1075-1084. doi: 10.2174/1871520614666140825105145. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9kn9s6c7 Anti-cancer agents in medicinal chemistry, vol 14, iss 8 |
| DOI: | 10.2174/1871520614666140825105145. |
| Popis: | © 2014 Bentham Science Publishers. Glioblastoma Multiforme (GMB) is the most aggressive primary brain tumor with poor survival rates and universal recurrence despite aggressive treatments. Recent research suggested that GBM has multiple glioma cell populations, some of which are organized in a stem cell hierarchical order with different stages of differention. Evidence indicated that recurrence is due to a development or persistance of a subpopulation of these tumor cells which are inherently resistant to treatment and these were defined as the glioma stem-like cells (GSC). It is hypothesized that GSC become highly malignant by accumulating mutations in oncogenic pathways. These cells present with specific surface markers which helps identify them. Targeting the surface markers as well as the signaling pathways of GSCs has been an ongoing research effort. This review focuses on summarizing the current treatment modalities used to glioblastoma treatments, evaluating their efficacy in controlling and eradicatig the GSCs, discussing the machanisms involved in GSC tumor proliferation and resistance to treatments in addition to proposing potential avenues to target GSCs in order to provide a potential cure for this cancer. |
| Databáze: | OpenAIRE |
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