Central administration of motilin stimulates feeding in rats
| Autor: | Thomas L. Garthwaite, David J. Rosenfeld |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Food intake Light media_common.quotation_subject Food consumption Experimental and Cognitive Psychology Peptide hormone Motilin Eating Behavioral Neuroscience Feeding behavior Internal medicine Animals Medicine Injections Intraventricular media_common business.industry digestive oral and skin physiology Rats Inbred Strains Appetite Stimulation Chemical Rats Endocrinology Gastrointestinal hormone business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Physiology & Behavior. 39:753-756 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/0031-9384(87)90261-7 |
| Popis: | Peripheral administration of motilin has been found to stimulate feeding behavior in rats. Since motilin immunoreactivity has been found in discrete brain sites, we tested the effect of motilin administered intracer-ebroventricularly on feeding in rats. Injection of 1 μg of motilin significantly increased food consumption at 2 hours, 22 hours, and at 24 hours in animals tested either at or 2 hr prior to lights out. Motilin also significantly increased food consumption in animals maintained under continuous lights-on at 2 hours (488% of control), 22 hours (128% of control), and at 24 hours (140% of control). |
| Databáze: | OpenAIRE |
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