Gynecologic cancers in pregnancy: guidelines based on a third international consensus meeting
| Autor: | Paul Berveiller, K. Van Calsteren, Ingrid A. Boere, Tineke Vandenbroucke, Michael J. Halaska, Charlotte Maggen, Matteo Lambertini, P. Poortmans, Robert Fruscio, Christianne A.R. Lok, Monica Fumagalli, M. van Gerwen, Frédéric Amant, M.M. van den Heuvel-Eibrink, Annette Hasenburg, Elyce Cardonick, Ignacio Zapardiel, A.L.V. Johansson, P. Morice, Flora Zagouri, Fedro A. Peccatori |
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| Přispěvatelé: | Medical Oncology, Amant, F, Berveiller, P, Boere, I, Cardonick, E, Fruscio, R, Fumagalli, M, Halaska, M, Hasenburg, A, Johansson, A, Lambertini, M, Lok, C, Maggen, C, Morice, P, Peccatori, F, Poortmans, P, Van Calsteren, K, Vandenbroucke, T, van Gerwen, M, van den Heuvel-Eibrink, M, Zagouri, F, Zapardiel, I, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Service de gynécologie et obstétrique [CHI Poissy-Saint Germain], CHI Poissy-Saint-Germain, Gamètes, implantation, gestation (GIG), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, University of Milan, University Hospital Kralovské Vinohrady, University Medical Center [Mainz], Karolinska Institutet [Stockholm], Ospedale Policlinico San Martino [Genoa], Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Département de chirurgie gynécologique [Gustave Roussy], Institut Gustave Roussy (IGR), European Institute of Oncology [Milan] (ESMO), Université Paris sciences et lettres (PSL), University Hospitals Leuven [Leuven], VU University Medical Center [Amsterdam], Princess Máxima Center for Pediatric Oncology [Utrecht, Netherlands], University of Athens Medical School [Athens], Hospital Universitario La Paz, Obstetrics, Faculty of Economic and Social Sciences and Solvay Business School |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Cognitive Genital Neoplasms Female International Cooperation [SDV.CAN]Life Sciences [q-bio]/Cancer Cancer Chemotherapy Cognitive Gynecologic Offspring Pregnancy [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics 03 medical and health sciences Genital Neoplasms Female/therapy Gynecologic Offspring 0302 clinical medicine SDG 3 - Good Health and Well-being Pregnancy Health care medicine Prenatal Exposure Delayed Effects/etiology Humans Chemotherapy Radiation treatment planning Intensive care medicine Societies Medical Cancer Pregnancy Complications Neoplastic/therapy Vaginal delivery business.industry Hematology medicine.disease Prognosis 3. Good health Cancer registry Long-term care 030104 developmental biology Oncology 030220 oncology & carcinogenesis Prenatal Exposure Delayed Effects Practice Guidelines as Topic Female Practice Guidelines as Topic/standards business Breast feeding Pregnancy Complications Neoplastic |
| Zdroj: | Annals of Oncology, 30(10), 1601-1612. Elsevier Ltd. Annals of Oncology Annals of Oncology, Elsevier, 2019, 30 (10), pp.1601-1612. ⟨10.1093/annonc/mdz228⟩ |
| ISSN: | 0923-7534 1569-8041 |
| DOI: | 10.1093/annonc/mdz228⟩ |
| Popis: | We aimed to provide comprehensive protocols and promote effective management of pregnant women with gynecological cancers. New insights and more experience have been gained since the previous guidelines were published in 2014. Members of the International Network on Cancer, Infertility and Pregnancy (INCIP), in collaboration with other international experts, reviewed existing literature on their respective areas of expertise. Summaries were subsequently merged into a manuscript that served as a basis for discussion during the consensus meeting. Treatment of gynecological cancers during pregnancy is attainable if management is achieved by collaboration of a multidisciplinary team of health care providers. This allows further optimization of maternal treatment, while considering fetal development and providing psychological support and long-term follow-up of the infants. Nonionizing imaging procedures are preferred diagnostic procedures, but limited ionizing imaging methods can be allowed if indispensable for treatment plans. In contrast to other cancers, standard surgery for gynecological cancers often needs to be adapted according to cancer type and gestational age. Most standard regimens of chemotherapy can be administered after 14 weeks gestational age but are not recommended beyond 35 weeks. C-section is recommended for most cervical and vulvar cancers, whereas vaginal delivery is allowed in most ovarian cancers. Breast-feeding should be avoided with ongoing chemotherapeutic, endocrine or targeted treatment. More studies that focus on the long-term toxic effects of gynecologic cancer treatments are needed to provide a full understanding of their fetal impact. In particular, data on targeted therapies that are becoming standard of care in certain gynecological malignancies is still limited. Furthermore, more studies aimed at the definition of the exact prognosis of patients after antenatal cancer treatment are warranted. Participation in existing registries (www.cancerinpregnancy.org) and the creation of national tumor boards with multidisciplinary teams of care providers (supplementary Box S1, available at Annals of Oncology online) is encouraged. ispartof: ANNALS OF ONCOLOGY vol:30 issue:10 pages:1601-1612 ispartof: location:England status: published |
| Databáze: | OpenAIRE |
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