Glucose Variability is Independently Correlated with Serum Level of Pigment Epithelium-Derived Factor in Type 2 Diabetes
| Autor: | Tomoki Fujikawa, Tsutomu Hirano, Takanori Matsui, Naoya Osaka, Ayako Fukase, Nobuko Sato, Tomoyasu Fukui, Hironori Yashima, Yasuyoshi Takahashi, Hideki Kushima, Munenori Hiromura, Sho-ichi Yamagishi, Michishige Terasaki, Yusaku Mori, Hiroe Nagaike, Makoto Ohara, Yo Kohata, Kyoko Shinmura |
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| Rok vydání: | 2021 |
| Předmět: |
pigment epithelium-derived factor
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Renal function 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine PEDF Internal medicine Diabetes mellitus Type 2 diabetes mellitus Internal Medicine medicine Continuous glucose monitoring Original Research business.industry Insulin nutritional and metabolic diseases Type 2 Diabetes Mellitus Glucose variability Cardiovascular disease medicine.disease Endocrinology Blood chemistry Oxidative stress business Body mass index |
| Zdroj: | Diabetes Therapy |
| ISSN: | 1869-6961 1869-6953 |
| DOI: | 10.1007/s13300-021-01008-y |
| Popis: | Introduction Pigment epithelium-derived factor (PEDF) may play a role in cardiometabolic disorders. The aim of this study was to investigate which biochemical and clinical parameters are independently associated with serum PEDF levels in patients with type 2 diabetes mellitus (T2DM). Methods We performed a cross-sectional analysis of 124 patients with T2DM who underwent continuous glucose monitoring (CGM) and blood chemistry analysis, including the diacron-reactive oxygen metabolites (d-ROMs) test and serum PEDF measurement (study 1). Then we investigated whether the changes in the studied biochemical and clinical parameters after 24 weeks of treatment (Δparameters) with anti-hyperglycemic agents, including sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide 1 receptor agonists, and/or insulin and anti-hypertensive drugs and statins, were independently correlated with change in PEDF (ΔPEDF) in 52 of the patients with T2DM for whom there was sufficient serum samples to perform the post-treatment analysis (study 2). Serum levels of PEDF were measured with an enzyme-linked immunosorbent assay. CGM metrics were calculated on days 2 and 3. Oxidative stress was evaluated using the d-ROMs test. Results Body mass index (BMI), triglycerides, fasting C-peptide, mean amplitude of glycemic excursions (MAGE), urinary albumin-to-creatinine ratio (UACR), and d-ROMs were positively associated with serum PEDF level, and high-density lipoprotein cholesterol (HDL-C) and estimated glomerular filtration rate (eGFR) were inversely associated with serum PEDF level. Because these parameters were correlated with each other, multivariate stepwise analysis was performed: eGFR, HDL-C, BMI, MAGE, and UACR remained significant (R2 = 0.452). Furthermore, ΔMAGE and Δd-ROMs were positively correlated with ΔPEDF in study 2. Conclusions The results of this study suggest that MAGE may be independently correlated with elevations in serum PEDF level in patients with T2DM. |
| Databáze: | OpenAIRE |
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