Antipsychotic drugs in Huntington’s disease
| Autor: | E Unti, Sonia Mazzucchi, Ubaldo Bonuccelli, Giovanni Palermo, Roberto Ceravolo |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Tetrabenazine antipsychotic drugs Huntington’s disease aggressiveness extrapiramidal side effects involuntary movements Disease law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Piperidines Randomized controlled trial Huntington's disease law medicine Humans Pharmacology (medical) Antipsychotic Adverse effect Psychiatry Intensive care medicine business.industry General Neuroscience Chorea medicine.disease 030227 psychiatry Pridopidine Huntington Disease chemistry Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Antipsychotic Agents medicine.drug |
| Zdroj: | Expert Review of Neurotherapeutics. 17:227-237 |
| ISSN: | 1744-8360 1473-7175 |
| DOI: | 10.1080/14737175.2016.1226134 |
| Popis: | The aim of this review is to overview the pharmacological features of neuroleptics experienced in the treatment of Huntington's disease (HD) symptoms. Despite a large number of case reports, randomized controlled trials (RCT) and drug comparison studies are lacking. Areas covered: After evaluating current guidelines and clinical unmet needs we searched PubMed for the term 'Huntington's disease' cross referenced with the terms 'Antipsychotic drugs' 'Neuroleptic drugs' and single drug specific names. Expert commentary: In clinical practice antipsychotics represent the first choice in the management of chorea in the presence of psychiatric symptoms, when poor compliance is suspected or when there is an increased risk of adverse events due to tetrabenazine. Antipsychotics are considered valid strategies, with the second generation preferred to reduce extrapyramidal adverse events, however they may cause more metabolic side effects. In the future 'dopamine stabilizers', such as pridopidine, could replace antipsychotics modulating dopamine transmission. |
| Databáze: | OpenAIRE |
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