Enantioselective Synthesis of Cephalimysins B and C

Autor:	Jakub Švenda, David Chalupa, Marek Nečas, Dražen Pavlović, Petra Vojáčková, Jiří Partl
Rok vydání:	2017
Předmět:	010405 organic chemistry Stereochemistry Chemistry Organic Chemistry Enantioselective synthesis Sequence (biology) Physical and Theoretical Chemistry 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Conjugate
Zdroj:	Organic letters. 19(4)
ISSN:	1523-7052
Popis:	The first synthesis of cephalimysins B and C is reported. The route features a Ni(II)–diamine-catalyzed enantioselective conjugate addition of a densely substituted 3(2H)-furanone and an efficient dihydroxylation–lactonization sequence as key steps in the assembly of the spirocyclic core. The fully synthetic strategy is amenable to analog preparation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d8315cafdf2beeceec4957dfdacb51 https://pubmed.ncbi.nlm.nih.gov/28157322 Zobrazit plný text záznamu