Biopsy Proven Fibrosis in Non-Alcoholic Fatty Liver Disease: An Analysis of Risk Factors
| Autor: | Ayaskant Singh, Shivaram Prasad Singh, Bijay Misra, Kaumudee Pattnaik, Preetam Nath, Sanjib Kumar Kar, Pallavi Bhuyan, Jayashree Rath |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Hepatology medicine.diagnostic_test business.industry Fatty liver nutritional and metabolic diseases Odds ratio medicine.disease digestive system Gastroenterology digestive system diseases 03 medical and health sciences Liver disease 0302 clinical medicine Fibrosis 030220 oncology & carcinogenesis Internal medicine Liver biopsy Biopsy medicine Original Article 030211 gastroenterology & hepatology Risk factor Steatohepatitis business |
| Zdroj: | Journal of Clinical and Experimental Hepatology. 8:367-374 |
| ISSN: | 0973-6883 |
| Popis: | Background Non-alcoholic fatty liver disease (NAFLD) is emerging as an important cause of liver disease in India. NAFLD is characterized by hepatic steatosis in absence of a significant alcohol use or other known liver disease. Non-alcoholic steatohepatitis (NASH) is a progressive form of NAFLD which deserves particular attention because it is more prone for development of fibrosis. Liver biopsy is the gold standard for diagnosis of NASH by evaluating necroinflammatory activity and stages of fibrosis. The aim of the study was to analyze liver biopsy specimens and identify risk factors associated with fibrosis in patients of NAFLD in eastern coastal India. Methods A total of 216 subjects with fatty liver in ultrasonography (USG) were selected for needle biopsy. Those NAFLD cases showing fibrosis in biopsy were analyzed for risk factors association. Results Definite NASH was diagnosed in 50 (23.14%), borderline NASH in 66 (30.55%) and not NASH in 100 (46.39%) of cases. Those patients with fibrosis (22%) were taken as cases and those without fibrosis (78%) were taken as controls for risk factor analysis. Age > 40 [odds ratio (OR) 2.01 (1.09–4.04)], female gender [OR 2.74 (1.24–6.05)], body mass index (BMI) > 23 [OR 15.36 (4.59–51.37)] and moderate fatty change in USG [OR 1.89 (1.01–3.62)] were observed as risk factors for progression to fibrosis in NAFLD cases. Conclusion Older age, females, obesity and moderate fatty liver on USG are risk factors for development of fibrosis in patients with NAFLD. Patients with these risk factors should be selected for liver biopsy and to be kept for close follow-up. |
| Databáze: | OpenAIRE |
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